Dr David Bowen

Dr David Bowen - Centenary Institute
Phone: +61 2 9565 6264
Email: d.bowen@centenary.org.au
Joint Head, Liver Immunology Program

Dr David Bowen is Joint Head of the Liver Immunology Program and is a member of Associate Faculty of Centenary Institute. He is a Gastroenterologist and Associate Professor of Medicine, Central Clinical School at University of Sydney.

Learn more about his Research Program.

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Publications

An antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses.

Tay SS, Wong YC, McDonald D, Wood NA, Roediger B, Sierro F, McGuffog CM, Alexander IE, Bishop GA, Gamble JR, Weninger W, McCaughan GW, Bowen DG* and Bertolino P*.

Proc. Natl. Acad. Sci. USA 111, E2540-2549 (IF: 9.8). (2014)

Intrahepatic activation of naive CD4 T cells by liver-resident phagocytic cells.

Tay SS, Wong YC, Roediger B, Sierro F, Lu B, McDonald D, McGuffog CM, Meyer N, Weninger W, Alexander IE, Heath WR, Bishop GA, Gamble JR, McCaughan GW, Bowen DG* and Bertolino P*.

J Immunol. 193, 2087-2095 (IF: 5.8). (2014)

Intrahepatic activation of naive CD4 T cells by liver-resident phagocytic cells.

Tay SS, Wong YC, Roediger B, Sierro F, Lu B, McDonald D, McGuffog CM, Meyer N, Weninger W, Alexander IE, Heath WR, Bishop GA, Gamble JR, McCaughan GW, Bertolino P* and Bowen DG*  (*equal last authors)

J Immunol 193(5):2087-95. doi: 10.4049/jimmunol.1400037. Epub 2014 Jul IF: 5.362

An antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses.

Tay SS, Wong YC, McDonald D, Wood NA, Roediger B, Sierro F, McGuffog CM, Alexander IE, Bishop GA, Gamble JR, Weninger W, McCaughan GW, Bertolino P*, Bowen DG* (*equal last authors)

Proc Natl Acad Sci USA, 2014; 111(25):E2540-9. IF: 9.737

Analysis of the intrahepatic ductular reaction and progenitor cell responses in hepatitis C virus recurrence post-liver transplantation.

Prakoso E, Tirnitz-Parker N, Kayali Z, Clouston A, Lee A, Ramm GA, Kench J, Bowen D, Olynyk J, McCaughan GW, Shackel NA

Liver Transplantation, 2014 20 (12); 1508-1519 IF:3.793

Naïve CD8 T cells activation by liver bone marrow-derived cells leads to a “neglected” IL-2low Bimhigh phenotype, poor CTL function and cell death.

Holz LE, Benseler V, Vo M, McGuffog C, Van Rooijen N, McCaughan GW, Bowen DG and Bertolino P.

J Hepatol. 57, 830-836 (IF: 9.3). (2012)

Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation.

Barbier L, Tay SS, McGuffog C, Triccas JA., McCaughan GW, Bowen DG and Bertolino P.

J Hepatol. 57, 352-358 (IF: 9.3). (2012)

Hepatocyte entry leads to degradation of autoreactive CD8 T cells.

Benseler V, Warren A, Vo M, Holz L, Tay SS, Le Couteur DG, Breen E, Allison A, van Rooijen N, McGuffog C, Schlitt HJ, Bowen DG, McCaughan GW and Bertolino P.

Proc. Natl. Acad. Sci. USA, 108, 16735-16740 (IF: 9.8). (2011)

Intrahepatic murine CD8 T cell activation associates with a distinct phenotype leading to Bim-dependent death

Holz L.E., Benseler V., Bowen D.G., Bouillet P., Strasser A., O’Reilly L., d’Avigdor WMH, Bishop A.G., McCaughan G.W. and Bertolino P.

Gastroenterology 135, 135:989-997 (IF: 12.0) (2008)

TLR4 activation mediates kidney ischemia/reperfusion injury.

Wu H., Chen G., Wyburn K.R., Yin J., Bertolino P., Eris J.M., Alexander S.I., Sharland A.F. and Chadban S.J.

J Clin Invest 117, 2847-2859 (IF: 14.2). (2007)

Primary T cell activation in the liver. Book chapter in Encyclopedia of Medical Immunology (Springer), Diamond and Davidson Editors

Bertolino P and Bowen DG

Editors in chief: MacKay and Rose. 899-905.

The liver; a special case in transplantation tolerance.

Benseler V, McCaughan GW, Schlitt HJ, Bishop GA, Bowen DG, Bertolino P.

Seminars in Liver Disease, 27, 194-213 (IF: 5.3).

Immune response to the Hepatitis C virus. Book chapter in Encyclopedia of Medical Immunology – Autoimmune diseases (Springer), Diamond and Davidson Editors

Bowen DG and Bertolino P

Editors in chief: MacKay and Rose, 476-486