The laboratory of Cardiovascular Signaling studies how blood vessel and heart form and maintain their function at molecular and cellular level. Cardiovascular system delivers oxygen, nutrients and circulatory cells to every part of human body and removes metabolic wastes. The precisely regulated development and function of heart and blood vessels are essential for the normal function of every organ systems.
Understanding of how blood vessels form and maintain has important implication in many human disease states such as congenital vascular diseases, stroke, cancer, wound healing, diabetic complications, coronary artery diseases and vascular dementia.
For many genetically associated vascular diseases, such as cerebral cavernous malformation (CCM) and aortic aneurysm, the efficient treatment strategy is still lacking, better understanding of how the malformed vessels develop should be the first step toward the search for therapeutic method.
Phone: +61 2 9565 6235
Head of Cardiovascular Signaling Laboratory Vascular Biology Program
Dr Xiangjian Zheng obtained his Ph.D in Molecular Medicine from Medical College of Georgia, where he studied lipid signaling in skin biology and endocrine control of blood pressure control. Zheng continued on his research in lipid signaling as a research fellow in Department of Pharmacology at Vanderbilt University School of Medicine. He used the combination of zebrafish model and lipidomics approaches to investigated lipid-mediated signaling in angiogenesis and cancer biology. After joined Penn Cardiovascular Institute at Perelman School of Medicine at University of Pennsylvania, Zheng’s research became more focused on human vascular diseases.