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Centenary Institute Medical Research

Computational BioMedicine

In the Computational BioMedicine lab, we develop integrative workflows combining various computational disciplines with experimentation to address questions around non-coding RNAs, post-transcriptional gene regulation and cancer biology.

Using machine learning, mathematical modelling, and molecular dynamics simulations we investigate mechanisms of post-transcriptional gene regulation. We found, for example, that synergistic target regulation by microRNAs is a widespread phenomenon of post-transcriptional gene regulation – a mechanisms that can be exploited to sensitize aggressive tumour cells to chemotherapy.

We develop multi-omics data analysis pipelines to investigate patterns of alternative splicing and other forms of gene regulation in normal biology and in various cancers. We identified intron retention as a well conserved form of alternative splicing that mediates cell-specific gene regulation. Aberrant intron retention has been described in multiple human cancers. We aim to identify regulators and consequences of intron retention as well as cross-talk with other forms of post-transcriptional gene regulation.

Centenary Institute Medical Research
Centenary Institute Medical Research

Dr Ulf Schmitz

Cancer Institute NSW Early Career Fellow
Associate Faculty, Centenary Institute
Conjoint Senior Lecturer, Sydney Medical School, University of Sydney
Phone: +61 2 9565 6209
Email: u.schmitz@centenary.org.au

Dr Ulf Schmitz is a computational biologist with training in bioinformatics and systems biology. He completed his PhD in June 2015 at the University of Rostock (Germany) under the supervision of Prof Olaf Wolkenhauer. In his PhD thesis, he investigated microRNA target regulation mechanisms by integrating multiple computational approaches. In July 2015, he joined the Centenary Institute as postdoctoral Research Officer in Prof John Rasko’s Gene and Stem Cell Therapy Program. Since January 2016, he also has an appointment as Conjoint Senior Lecturer at the Sydney Medical School.

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