The DNA Repair Laboratory studies antibody mutation in activated B cells, which is initiated by the DNA editing enzyme “AID”. B cells mutate their antibody genes at extremely high rates during infections, to rapidly optimise the ability of the antibodies they make to neutralise the infecting pathogen. “Off-target” mutation of oncogenes by AID underlies most adult B cell cancers, so we seek to understand why AID-induced DNA damage leads to mutation, when similar DNA damage is generally repaired faithfully.
DR CHRISTOPHER JOLLY, Head of Laboratory
Medicine, Central Clinical School
Phone: (02) 9565 6188
Fax: (02) 9565 6101
PhD: Macquarie University/CSIRO, Sydney – 1993
Postdoctoral Fellow, John Curtin School of Medical Research, ANU, Canberra – 1993-1994 Postdoctoral Fellow: MRC Laboratory of Molecular Biology, Cambridge, UK – 1995-1997 Group Leader, Centenary Institute, Sydney – 1998-present
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