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Cooperative gene regulation by miRNA pairs and their identification using a computational workflow

In this article, we present a computational workflow for the prediction and analysis of cooperating miRNAs and their mutual target genes. The workflow integrates methods of miRNA target prediction; triplex structure analysis; molecular dynamics simulations and mathematical modelling for a reliable prediction of functional RNA triplexes and target repression efficiency. Many of these approaches will be expanded in the current project.

Schmitz U, Lai X, Winter F, Wolkenhauer O, Vera J, Gupta S

Nucleic Acid Research

Date: 2014

42, 12, p. 7539- 7552