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Intron retention enhances gene regulatory complexity in vertebrates

We uncovered new and unanticipated conserved characteristics of intron-retaining transcripts. We found that intron-retaining genes are transcriptionally co-regulated from bidirectional promoters. Intron-retaining genes have significantly longer 3′ UTR sequences, with a corresponding increase in miRNA binding sites, some of which include highly conserved sequence motifs. This article was recommended by F1000Prime.

Schmitz U, Pinello N, Jia F, Alasmari S, Ritchie W, Keightley M-C, Shini S, Lieschke GJ, Wong JJ-L, Rasko JEJ

Genome Biology

Date: 2017

18.1: 216