Home > Publications > MiR-205-5p and miR-342-3p cooperate in the repression of the E2F1 transcription factor in the context of anticancer chemotherapy resistance

MiR-205-5p and miR-342-3p cooperate in the repression of the E2F1 transcription factor in the context of anticancer chemotherapy resistance

In this article, we integrated bioinformatics, structural modelling, kinetic modelling, and experiments to find new avenues for overcoming chemotherapy resistance in aggressive tumour cells. Our results suggest that pairs of cooperating microRNAs could be used as potential RNA therapeutics to reduce E2F1-related chemoresistance.

Lai X*, Gupta SK*, Schmitz U*, Marquard S, Knoll S, Wolkenhauer O, Puetzer B, Vera J *co-first author

Theranostics

Date: 2018

8(4): 1106-1120