Home > Publications > Progressive Liver Injury in Chronic Hepatitis C Infection Correlates with increased Intrahepatic expression of Th1-Associated Cytokines.

Progressive Liver Injury in Chronic Hepatitis C Infection Correlates with increased Intrahepatic expression of Th1-Associated Cytokines.

This paper was the first to quantitate the inflammatory cytokine pattern in chronic HCV infection. It was a landmark paper as the paradigm at the time described chronic HCV as a TH2 type disease. Together with our parallel paper ( Hepatology IF 12.003, 111 citations )that showed that intrahepatic viral loads did not correlate with liver injury this set up an understanding of this infection for the next 15 years defining that the host response to the virus was the key factor in driving liver injury.

Napoli J, Bishop GA, Painter DM, McGuinness P and McCaughan GW.

Hepatology, 1996; 24:759-765.

Date: 1996