Abstract AID deaminates C to U in either strand of Ig genes, exclusively producing C: G/G: C
to T: A/A: T transition mutations if U is left unrepaired. Error-prone processing by UNG2 or
mismatch repair diversifies mutation, predominantly at C: G or A: T base pairs, respectively.
Here, we show that transversions at C: G base pairs occur by two distinct processing
pathways that are dictated by sequence context. Within and near AGCT mutation hotspots,
transversion mutation at C: G was driven by UNG2 without requirement for mismatch …
Nucleic Acids Research
Volume 45 | Issue 6