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The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury.
This is a recent paper that has brought clarity to the field of the role of Hedgehog pathway in responding to liver injury. It has already lead to letters to the editor in Hepatology and J.Hepatology – the two leading journals in the field.
Grzelak CA, Martelotto LG, Sigglekow ND, Patkunanathan B, Ajami K, Calabro SR, Dwyer BJ, Tirnitz-Parker JE, Watkins DN, Warner FJ, Shackel NA, McCaughan GW.
J Hepatol. 2014 Jan;60(1):143-51
Date: 2014