In this review, we discuss the state of the art in RNA systems biology with focus on the application in the systems biomedicine field. We propose guidelines for analysing the role of miRNAs and long non-coding RNAs in human diseases. We introduce RNA expression profiling and network approaches for the identification of stable and effective RNomics-based biomarkers, providing insights into the role of ncRNAs in disease regulation. Finally, we discuss avenues for the computer-aided design of novel RNA-based therapeutics.
Briefings in Bioinformatics