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The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity.

This paper described for the first time that activation of T cells in the liver but not systemic lymphoid tissue lead to tolerance and that liver injury (allograft rejection or hepatitis) required T cell activation in lymph nodes or spleen

Bowen DG, Zen M, Holz L, Davis T, McCaughan GW, Bertolino P.

J Clin Invest. 2004;114:701-712

Date: 2004