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Centenary Institute - Medical Research
Centenary Institute - Medical Research


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Medical Research Seminar: Barrier Immune Responses

July 15 @ 12:00 pm - 1:00 pm

Medical Research Seminar: Regulation of barrier immune responses by integrins and TGFβ

Professor Mark Travis

Professor of Immunology, University of Manchester


Barrier surfaces such as the lung and intestine contain a huge number of immune cells that are poised to attack harmful micro-organisms, but must be tightly regulated to ignore innocuous environmental substances and commensal micro-organisms. Work in my lab has focussed on how the crucial cytokine TGFβ regulates immune responses at barrier sites. Using animal models and human clinical samples, our studies have uncovered novel pathways by which integrins activate TGFβ to control innate and adaptive immunity in the lung and intestine. Such work aims to identify novel therapeutic targets for inflammatory diseases by targeting TGFβ activity in specific contexts.


Mark is a Professor of Immunology based in the Lydia Becker Institute of Immunology and Inflammation and the Wellcome Trust Centre for Cell-Matrix Research at the University of Manchester, UK.

Mark received a PhD in protein biochemistry from the University of Manchester in 2004, studying the structure and function of integrins. He went to the University of California, San Francisco as an American Lung Association Fellow, where he first started working on how integrins and TGFβ regulate immunity. Mark returned to Manchester as a Royal Commission Fellow in 2006, before becoming an RCUK Fellow in October 2007. Mark became a Lecturer in 2012, a Senior Lecturer in 2015 and Professor of Immunology in 2018.

More information on Professor Mark Travis here.

Download the poster here.


July 15
12:00 pm - 1:00 pm
Event Category:


Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia