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Centenary Institute - Medical Research
Centenary Institute - Medical Research


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Medical Research Seminar: Coagulation Disorders

July 18 @ 12:00 pm - 1:00 pm

Medical Research Seminar: Coagulation disorders: fishing for new insights using genome editing

Dr Jordan Shavit

Associate Professor, University of Michigan


Significant progress has been made in our understanding of blood coagulation, but unknown genes contribute to the variable disease severity observed among patients with clotting disorders. Understanding such modifiers might classify patients at higher risk as well as identify novel therapeutic targets. We use zebrafish to conduct large scale interrogation of the genome to discover genes with the potential to modify the severity of human coagulation disorders. Using genome editing we have developed clotting factor mutant lines and conducted mutagenesis experiments which may identify interactions amongst known coagulation factors as well as unknown modifiers of these pathways.


Jordan Shavit graduated from the University of Michigan, received a Ph.D. and M.D. from Northwestern University. He then pursued a residency in Pediatrics and a fellowship in Pediatric Hematology/ Oncology both at the University of Michigan where he is now an associate professor and the Henry and Mala Dorfman Family Professor of Pediatric Hematology/Oncology. Dr. Shavit specializes in the care of pediatric patients with blood clotting disorders, and his laboratory has developed zebrafish models of human bleeding and thrombotic disorders using genome editing technologies.

More information on Dr Jordan Shavit here.

Download the poster here.


July 18
12:00 pm - 1:00 pm
Event Category:


Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia