- This event has passed.
Medical research seminar: COPD: factors, triggers and comorbidities
September 21 @ 12:00 pm - 1:00 pm
Associate Professor Margaret Hibbs
About the Talk: My lab has developed a major interest in defining pathways that induce chronic lung inflammation, focusing on one of the world’s most common and deadly lung diseases, chronic obstructive pulmonary disease (COPD), creating novel models and new analytical techniques. We showed that macrophage subsets exist in the chronically inflamed lung, and undertook translational studies that revealed analogous inflammatory profiles exist in the lungs of both mice and human patients. Our studies have revealed that the myeloid growth factor G-CSF plays a key role in the development of experimental COPD and extra- pulmonary comorbidities, and notably, in translational studies, we demonstrated elevated levels of G-CSF in patients with COPD and in smokers prone to COPD, indicating its potential as a disease biomarker. In new studies we have developed a model of bronchopulmonary dysplasia (BPD), showing that early life high oxygen exposure leads to concurrent lung and retinal damage in later life and we have found key roles for two growth factors in early life lung injury. We have recently defined a new biomarker that links lung function decline, COPD and lung cancer.
About the Speaker: A/Prof Margaret Hibbs is Head of the Leukocyte Signalling Lab in the Department of Immunology and Pathology at Monash University. Margaret completed a PhD at the University of Melbourne and undertook postdoctoral training at Harvard Medical School in Boston and the Ludwig Institute for Cancer Research in Melbourne. Margaret’s research program utilises a range of immunological and histopathological techniques and preclinical models to improve our understanding of the mechanisms that lead to chronic inflammation and the development of chronic inflammatory diseases, particularly diseases such as lupus and chronic obstructive pulmonary disease.