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Centenary Institute - Medical Research
Centenary Institute - Medical Research

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Medical Research Seminar: CRISPR-Cas13 reprogramming for precise silencing of tumour and viral RNAs

October 5 @ 12:00 pm - 1:00 pm

Dr Fareh Mohamed

Peter MacCallum Cancer Centre

About the talk: In this talk, Mohamed will present single-nucleotide resolution screens, comprehensive mutagenesis, and in silico analysis approaches that allowed the team to uncover the molecular bases of Cas13 target recognition and silencing. This talk will cover de novo design of Cas13 to silence tumour RNAs that drive tumorigenesis in cell models. Mohamed will also discuss Cas13 reprogramming to suppress replication-competent SARS-CoV-2 viruses and show its resilience to new variants thanks to a single-nucleotide mismatch tolerance mechanism (Nature Comms, 2021).

About the speaker:
 Mohamed Fareh is a senior research fellow with a multidisciplinary backgroundin RNA biology, CRISPR, cancer, and advanced single-molecule biophysics. He obtained his Ph.D. in 2012 (France), where he uncovered a subset of non-coding RNAs that regulate cell plasticity in brain tumours. He did his postdoctoral training in the single-molecule Biophysics lab (Joo lab, TU Delft, The Netherlands), where he pioneered new single- molecule approaches to investigate the biology of non-coding RNAs and CRISPR effectors with nanometre spatial and millisecond temporal resolution. In August 2018, Mohamed relocated to Australia to join the Trapani lab at the Peter MacCallum Cancer Centre (Melbourne). He leads projects focusing on reprogramming RNA-targeting CRISPR effectors called CRISPR-Cas13 for transcriptome remodelling with single-base precision. His team is interested in (i) understanding the molecular basis of RNA recognition by CRISPR-Cas13, and (ii) reprogramming CRISPR-Cas13 to silence undruggable tumour drivers and viral transcripts.
Read more about Dr Fareh Mohamed’s work here.

Details

Date:
October 5
Time:
12:00 pm - 1:00 pm
Event Category:
https://forms.gle/UcuHw787BbgtMY2w5

Venue

Online meeting