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Centenary Institute - Medical Research
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Medical Research Seminar: Gut Microbiome and Metabolites in NAFLD and NAFLD-HCC

November 23 @ 12:00 pm - 1:00 pm

Professor Jun Yu
Department of Medicine and Therapeutics, The Chinese University of Hong Kong

About the talk: Non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is an emerging malignancy worldwide. However, the molecular mechanism of NAFLD-HCC is largely unknown, and targeted therapy is currently not available (Yu J et al, Semin Cancer Biol 2013). We identified the link of cholesterol to NASH and NASH-HCC and provide potential therapeutic targets (Yu J et al. Nature Commun 2018). Moreover, SQLE, the rate-limiting enzyme in cholesterol biosynthesis, is highly expressed in human NAFLD-HCCs. Hepatocyte-specific Sqle transgenic mice accelerated the development of NAFLD (Yu J et al. Gastroenterology 2021) and HFHC-HCC and is a therapeutic target (Yu J et al. Sci Transl Med 2018). Dietary cholesterol induced gut bacterial metabolites alteration including increased Taurocholic acid and decreased 3-Indolepropionic acid. Germ-free mice gavaged with stools from mice fed HFHC manifested hepatic lipid accumulation, inflammation, immunity change and cell proliferation. Moreover, Atorvastatin (cholesterol inhibitor) restored cholesterol-induced gut microbiota dysbiosis and metabolomics changes, which completely prevented NAFLD-HCC development (Yu J et al. Gut 2020).  Collectively, cholesterol drives NAFLD-HCC formation by inducing alteration of gut microbiota and metabolites in mice. Cholesterol inhibitory therapy and gut microbiota manipulation may be effective strategies for NAFLD-HCC prevention.

About the speaker: Jun Yu (MD, PhD) is Choh-Ming Li Professor, Director of Institute of Digestive Disease, Director of State Key Laboratory of Digestive Disease, Assistant dean of faculty of Medicine, The Chinese University of Hong Kong. Her research interests being fatty-liver disease, liver cancer and GI cancer. She has 486 peer-reviewed publications (ISI citation>25,000, H-index=81). She obtained 30 prestigious awards, including The National Natural Science Award 2020; Top 10 Scientists in Global Gut Microbiome Research 2019 (Gut Daily); AGA Council Oncology Research Mentor Award 2017; National Natural Science Award 2016; Croucher Senior Research Fellowship 2016; National Science and Technology Progress Award 2012.

Read more about Professor Jun Yu’s work here.

Details

Date:
November 23
Time:
12:00 pm - 1:00 pm
Event Category:
https://forms.gle/UcuHw787BbgtMY2w5

Venue

Online meeting