Professor Anca Dorhoi
Head, Institute of Immunology, Professor of Immunology, Friedrich Loeffler Institut University of Greifswald
Tuberculosis (TB) remains the leading cause of death by a single infectious agent worldwide. Despite decades of active research, host factors promoting susceptibility to Mycobacterium tuberculosis (Mtb), the etiologic agent of human TB, are still ill defined. We investigated cellular determinants of TB progression during experimental murine infection and employed in vitro models of granuloma. We unveiled myeloid-derived suppressor cells and platelets as novel regulators of TB pathogenesis. Detailed characterization of their cross talk with immune cells, their dynamics at the site of infection as well as identification of molecular entities critical for TB control by these new cellular regulators may pave ways for new interventions against this deadly disease.
Anca Dorhoi studied veterinary medicine at and obtained her doctoral degree from the Faculty of Veterinary Medicine Cluj-Napoca, Romania in 2004. She completed a postdoctoral training at the Dept. of Immunology (head SHE Kaufmann), Max Planck Institute for Infection Biology in Berlin, Germany and in 2015 became a Minerva Group Leader at same institute. Since 2017 she is Director of IfI at the FLI, Professor of Immunology at UG, Speaker of the Working Group Immunology of Infection of the German Society for Immunology. Her work focuses on innate immunity to bacterial pathogens, particularly to virulent mycobacteria causing tuberculosis.
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