Associate Professor John F Rawls
Department of Molecular Genetics and Microbiology, Duke University School of Medicine
We seek to understand how the intestinal microbiome contributes to vertebrate physiology and disease. To that end, we leverage complementary zebrafish and mouse models to study the physiology of host-microbiome interactions. This work has identified novel and conserved mechanisms by which intestinal bacteria regulate dietary fat metabolism and systemic innate immunity. We also apply genomic approaches in these animal models to understand the transcriptional regulatory pathways utilized by the intestinal epithelium to mediate host responses to the microbiome. Using this approach, we have identified mechanisms of transcriptional and chromatin regulation that have been conserved during vertebrate evolution and also contribute to modern human diseases such as the inflammatory bowel diseases, obesity, and diabetes.
John Rawls is an Associate Professor in the Department of Molecular Genetics and Microbiology, with secondary appointments in the Duke Microbiome Center, the Center for Host-Microbial Interactions, and the Duke Cancer Institute. After completing his undergraduate education at Emory University (1992-1996), he received a Ph.D. in Developmental Biology from Washington University under the mentorship of Dr. Stephen Johnson (1996-2001). He then trained as a postdoctoral fellow with Dr. Jeffrey Gordon at the Center for Genome Sciences at Washington University (2001-2006). Prior to joining Duke, he was a faculty member at the University of North Carolina at Chapel Hill (2006-2013).
Read more about Associate Professor John Rawls here.
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