Professor Graham Lieschke
Group Leader, Australian Regenerative Medicine Institute, Monash University
Neutrophils and macrophages are the front-line phagocytes involved in host defence. While much is known about their development and function, it is only recently that intravital imaging has provided the spatiotemporal resolution necessary to observe them doing their job in vivo. From live imaging of neutrophils and macrophages in zebrafish models, we have observed new aspects neutrophil morphology and function during infection and inflammation. In particular, to study these cells at unprecedented spatiotemporal resolution, we have used lattice light sheet microscopy. Our recent studies have examined the hypothesis that neutrophil nuclear plasticity is critical to neutrophil migratory behaviour in vivo. This has required defining the normal behaviour of nuclei during neutrophil migration, and an examination of how this alters when various structural components are altered.
Graham Lieschke is a clinician/scientist. He studied medicine at University of Melbourne and gained his FRACP as Medical Oncologist focusing on haematological malignancies. As a clinical research fellow, he was involved in the first clinical studies of G-CSF and GM-CSF. His PhD at the Ludwig Institute generated one of Australia’s first knock out mice, the G-CSF deficient mouse. His postdoctoral training at the Whitehead Institute in Boston generated novel bioactive single chain forms of interleukin-12 and systems to express them. His research laboratory in Melbourne has been at the Ludwig Institute, Walter and Eliza Hall institute, and now at the Australian Regenerative Medicine Institute at Monash University. His group studies leukocyte development and function using zebrafish models. This has included forward genetic screening to identify a diverse group of new genes on which myelopoiesis depends, and reverse genetic studies of gene implicated in myeloid failure disorders. From collaborations modelling infectious diseases in zebrafish, he has become fascinated by the opportunity that optically transparent zebrafish provide for live cell imaging of neutrophil function in vivo. He practises as a Clinical Haematologist at the Royal Melbourne Hospital and Peter MacCallum Cancer Centre, working in the team managing patients with aggressive lymphoma. He also has a life-long passionate interest in the music of JS Bach, as an organist and a conductor.
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