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Centenary Institute - Medical Research
Centenary Institute - Medical Research

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Medical Research Seminar: Mucosal Macrophage Function

July 12 @ 12:00 pm - 1:00 pm

Medical Research Seminar: Regulation of mucosal macrophage function by the microbiota

Dr Elizabeth Mann
Research Fellow/Principal Investigator, University of Manchester

Abstract

Macrophage function is tightly regulated at mucosal sites such as the gut and the lung to avoid overreactive immune responses against the huge amount of harmless antigens these sites are exposed to daily. The intestine contains trillions of harmless bacteria (commensal microbiota) and accordingly, the immune system has adapted to become hypo-responsive to bacterial stimulation to avoid inflammation. Similarly, the lungs are exposed to inhaled antigens constantly and regulatory immune mechanisms prevent allergy and airway hypersensitivity in healthy individuals. My work dissects the specific roles of macrophages in these regulatory processes, how their function is specifically tailored to their tissue of residence, and how macrophage function is regulated by the microbiota.

Bio

PhD: Professor Stella Knight – Imperial College London (tissue specific properties of human dendritic cells) 2007-2011.

Postdoc: (Stayed on at Imperial College) Intestinal dendritic cells and inflammatory bowel disease 2011-2013

Postdoc 2: Johns Hopkins University (Dr Xuhang Li’s lab), mouse models of colitis and effects of the microbiota in shaping immune responses 2013-2015

Postdoc 3: Glasgow University with Professor Simon Milling. Began to study in depth the functions of intestinal macrophages and how this is regulated by the microbiota. 2015-2017

Principal Investigator: Awarded Wellcome Trust/ Royal Society Henry Dale Fellowship to set up own lab at the University of Manchester 2017 – 2022.

Read more on the work of Dr Elizabeth Mann here.

Download the poster here.

Details

Date:
July 12
Time:
12:00 pm - 1:00 pm
Event Category:

Venue

Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia
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