Dr Elizabeth Mann
Research Fellow/Principal Investigator, University of Manchester
Macrophage function is tightly regulated at mucosal sites such as the gut and the lung to avoid overreactive immune responses against the huge amount of harmless antigens these sites are exposed to daily. The intestine contains trillions of harmless bacteria (commensal microbiota) and accordingly, the immune system has adapted to become hypo-responsive to bacterial stimulation to avoid inflammation. Similarly, the lungs are exposed to inhaled antigens constantly and regulatory immune mechanisms prevent allergy and airway hypersensitivity in healthy individuals. My work dissects the specific roles of macrophages in these regulatory processes, how their function is specifically tailored to their tissue of residence, and how macrophage function is regulated by the microbiota.
PhD: Professor Stella Knight – Imperial College London (tissue specific properties of human dendritic cells) 2007-2011.
Postdoc: (Stayed on at Imperial College) Intestinal dendritic cells and inflammatory bowel disease 2011-2013
Postdoc 2: Johns Hopkins University (Dr Xuhang Li’s lab), mouse models of colitis and effects of the microbiota in shaping immune responses 2013-2015
Postdoc 3: Glasgow University with Professor Simon Milling. Began to study in depth the functions of intestinal macrophages and how this is regulated by the microbiota. 2015-2017
Principal Investigator: Awarded Wellcome Trust/ Royal Society Henry Dale Fellowship to set up own lab at the University of Manchester 2017 – 2022.
Read more on the work of Dr Elizabeth Mann here.
Download the poster here.