Associate Professor Danny Hatters
NHMRC Senior Research Fellow, Department of Biochemistry and Molecular Biology
University of Melbourne
The abnormal aggregation of proteins into insoluble deposits is a major hallmark of many diseases including the most common neurodegenerative conditions. How these deposits arise and impact on neuronal health have remained outstanding key research questions for the last 2 decades. One major hypothesis is that protein homeostasis (proteostasis) becomes unbalanced and leads to proteins misfolding, mislocalizing and accumulating as aggregates. Here I will discuss our recent research that has illuminated the mechanisms for how aggregation of the Huntington disease protein Huntingtin impacts cell health and new approaches we have developed for measuring proteostasis imbalance.
Danny Hatters runs a research laboratory to study how proteins misfold and interfere with cellular functions, with a particular focus on mechanisms related to neurodegenerative disease. The research combines building new tools, biosensors and methods using various aspects of protein biochemistry and cell biology. He completed his PhD at the University of Melbourne in 2002. He then completed his post doc at the Gladstone Institutes/University of California, San Francisco from 2002-2007 before returning to the University of Melbourne. He currently is an NHMRC Senior Research Fellow and Deputy Head of Department.