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Medical Researcher Seminar: Biophysical nanotools for membrane dynamics

June 1 @ 12:00 pm - 1:00 pm

Medical Researcher Seminar: Biophysical Nanotools for Membrane Dynamics at Single-Cell and Single-Molecule Level

Dr Qian Peter Su

University of Technology Sydney

About the talk: We have established biophysical nanotools including in vitro single-molecule reconstitution assays and super-resolution microscopy systems for the study of intracellular membrane dynamics, especially for autolysosome tubulation, mitochondrial network formation and human platelet spreading. Intracellular membrane nanotube formation and its dynamics play important roles for cargo transportation and organelle biogenesis, which are mainly driven by motor proteins. The formation and dynamics of nanotubes are increasingly recognized to play important roles in a multitude of biological progresses. We demonstrated the role of nanotube dynamics in autophagic lysosome reformation (ALR) during autophagy [1,2] and mitochondrial network remodelling [3] with single-molecule in vitro reconstitution assay and super-resolution fluorescent microscopy. The Australia-map like image on the right is an activated human platelet – a blood clotting cell that plays a crucial role in preventing bleeding or causing the cardiovascular diseases, such as heart attack and stroke. The cell was immuno-stained towards integrin αIIbβ3 and the image was taken by STochastic Optical Reconstruction Microscopy (STORM), the Australia’s first super resolution cardiovascular imaging platform with spatial resolution ~20 nm. This single-molecule nanotool will provide better guidance to understand how platelets make thrombotic decision at single-cell and single-molecule level, potentially leading to new anti-thrombotic strategies.

About the speaker: Dr Qian Peter SU is now an EL1 Fellow of NHMRC, Postdoctoral Fellow of Heart Foundation (co-fund) and Lecturer at UTS. He is also a visiting scientist at the Heart Research Institute (HRI) and Centenary at USyd. He received PhD in Biophysics supervised by Profs X.Sunney XIE and Yujie SUN from Peking University, China with a joint training at Harvard University, US (visiting scholar 2012). His research program named “Quantitative Imaging at Nanoscale with SUper-resolution (QIAN SU)” bridges applied biomedical engineering with fundamental sciences. It brings new insights to mechanistic questions addressed at single-molecule level by advanced microscopy and acquired with high spatiotemporal resolution.

Read more about Dr Qian Peter Su work here.

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June 1
12:00 pm - 1:00 pm
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