A/Prof Philip Gregory
University of South Australia and SA Pathology
About the talk: MicroRNAs are important regulators of gene expression, strongly repressing some target genes and orchestrating changes within whole gene networks. Here, I will discuss our findings on two miRNAs involved in cancer metastasis. MiR-200 strongly represses key proteins involved in gene transcription and RNA splicing with downstream consequences on cell plasticity. In contrast, miR-342 exerts modest but broad effects on gene networks that promote breast cancer metastasis. These studies highlight the diverse functions of miRNAs in cancer progression.
About the speaker: A/Prof Philip Gregory leads the Gene Regulation in Cancer Laboratory at the Centre for Cancer Biology (an alliance of University of SA and SA Pathology). His research focuses on uncovering molecular pathways that influence cell plasticity and the metastasis of breast and prostate cancers.He pioneered the identification of microRNA feedback loops as key regulators of epithelial-mesenchymal transition. More recently, his research has demonstrated the importance of alternative splicing networks (including circular RNAs) in influencing cell plasticity. His work has been published in journals including Nature Cell Biology, Cell, and EMBO Journal and has been widely cited (>10K).
Read more about A/Prof Philip Gregory’s work here.
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