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Centenary Institute - Medical Research
Centenary Institute - Medical Research


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Tracking tumor metastasis at high spacio-temporal resolution

23/10/2018 @ 12:00 pm - 1:00 pm

Dr Jacky Goetz
Head, The Goetz Lab for Tumor Biomechanics

Three reasons explain why most of the critical events driving normal and pathological scenarios had been less investigated: they occur rarely in space and time, they are highly dynamic, they differ when studied in situ in an entire living organism. Metastasis is the primary cause for cancer-related mortality, but its mechanisms remain to be elucidated. Intravital imaging has opened the door to in vivo functional imaging in animal models of cancer, however it is limited in resolution. Ultrastructural analysis of tumor metastasis in vivo has so far been hindered by the limited eld of view of the electron microscope, making it dif cult to retrieve volumes of interest in complex tissues. We recently developed a multimodal correlative approach allowing us to rapidly and accurately combine functional in vivo imaging with high-resolution ultrastructural analysis of tumor cells in a relevant pathological context. The multimodal correlative approach that we propose here combines two-photon excitation microscopy (2PEM), microscopic X-ray computed tomography (microCT) and three-dimensional electron microscopy (3DEM). It enables a rapid and accurate correlation of functional imaging to high- resolution ultrastructural analysis of tumor cells in a relevant pathological context. This reliable and versatile work ow offers access to ultrastructural details of metastatic cells with an unprecedented throughput opening to crucial and unparalleled insights into the mechanisms of tumor invasion, extravasation and metastasis in vivo.

Jacky graduated in Pharmacology and Cell Biology from University of Strasbourg (France) where he studied astrocytoma cell migration in the laboratory of Ken TAKEDA. He then moved to the laboratory of Ivan Robert NABI in Montreal (University of Montreal, Canada), and later in Vancouver (University of British Columbia, Canada), where he rst studied the interaction between the endoplasmic reticulum and mitochondria. He was in parallel interested in glycosylation of membrane proteins, in particular integrins, and described its importance, in concert with Caveolin-1 (Cav1), in bronectin brillogenesis, focal adhesion dynamics and tumor cell migration. He received his Ph.D. degree in 2007 from both University of Montreal and University of Strasbourg. He then moved to the CNIC in Madrid (Spain) in the laboratory of Miguel Angel del Pozo where he led a study on the implication of Cav1 in biomechanical remodeling of the microenvironment and showed its importance in normal tissue architecture but especially during tumor progression. He then joined the team of Julien VERMOT at the IGBMC in Strasbourg (France) to pursue his interests in mechanotransduction phenomenons using zebra sh as a model. He recently won the SBCF Young Scientist Prize for his contribution to Cell Biology and started his team Tumor Biomechanics in 2013 where he develops his growing interest for the role played by biomechanical forces during tumor progression.

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12:00 pm - 1:00 pm
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Centenary Institute Lecture Theatre