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July 2019

Medical Research Seminar: Mucosal Macrophage Function

July 12 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

My work dissects the specific roles of macrophages in these regulatory processes, how their function is specifically tailored to their tissue of residence, and how macrophage function is regulated by the microbiota.

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Medical Research Seminar: Barrier Immune Responses

July 15 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Barrier surfaces such as the lung and intestine contain a huge number of immune cells that are poised to attack harmful micro-organisms, but must be tightly regulated to ignore innocuous environmental substances and commensal micro-organisms.

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Medical Research Seminar: Coagulation Disorders

July 18 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Significant progress has been made in our understanding of blood coagulation, but unknown genes contribute to the variable disease severity observed among patients with clotting disorders.

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Research Seminar: Neutron Star Merger

July 23 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

The LIGO-Virgo interferometer detected gravitational waves from a neutron star merger in a galaxy 130 million light years away. This was a breakthrough for physics and astronomy.

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August 2019

Medical Research Seminar: Advancing GPCR structure

August 13 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

G protein-coupled receptors (GPCRs) are the largest family of cell surface drug targets. Consequently, there is high interest in understanding the structure of members of this receptor superfamily and molecular detail of how ligands and transducer proteins interact with the receptors.

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Medical Research Seminar: Anti-tumor immunity

August 20 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Altered expression, function or localisation of epigenetic enzymes and/or their partner proteins can play a crucial role in cancer onset and progression. I will present data showing that BETi can affect anti-tumor immune response through effects on both the target tumor cells and on immune cells.

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Medical Research Seminar: Intravital imaging studies

August 27 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Neutrophils and macrophages are the front-line phagocytes involved in host defence. From live imaging of neutrophils and macrophages in zebrafish models, we have observed new aspects neutrophil morphology and function during infection and inflammation.

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September 2019

HRI & CI Medical Research Seminar: The Inflammatory Index

September 3 @ 12:00 pm - 1:00 pm
Charles Perkins Centre, Level 6 Seminar Room, University of Sydney
Camperdown, NSW 2006 Australia
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Inflammation is a double-edged weapon. When localized and moderate, it is beneficial – aiding the resolution of infections and healing. When excessive and systemic, it becomes a problem – host tissues may be damaged by its ‘friendly fire’. Mechanisms have thus evolved to keep inflammation under tight control. The seminar will describe what we know about how the Inflammation Reflex works and what may be its biological and medical significance.

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Medical Research Seminar: Data science and Stem Cell Biology

September 10 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

In this talk, I will first showcase a seminal work where integrative methods were used for discovering fundamental mechanisms in stem cells.

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Medical Research Seminar: Chronic conditions and infections

September 17 @ 8:00 am - 5:00 pm

Obesity and type 2 diabetes confer susceptibility to numerous different complications, including severe influenza virus infections. Here, I will discuss our latest research in our understanding of the role of both obesity and diabetes in severe influenza virus infections and what this means for influenza pandemic preparedness.

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