The Ochiai Laboratory is working on the development of new experiments and technologies that combine genome editing, cell biology, and live-cell imaging technologies to measure transcriptional dynamics and to elucidate the molecular mechanisms of gene expression heterogeneity in mouse embryonic stem cells.

Recent advances in genome editing technology suggest that CRISPR-Cas9 synthetic gene drives could be used as an alternative, humane strategy for invasive rodent population control. However, despite their potential, this has only been developed in a small number of species including flies, mosquitoes and yeast.

Investigations of cellular determinants of Tuberculosis progression during experimental murine infection and employed in vitro models of granuloma. We unveiled myeloid-derived suppressor cells and platelets as novel regulators of TB pathogenesis.

We have identified mechanisms of transcriptional and chromatin regulation that have been conserved during vertebrate evolution and also contribute to modern human diseases such as the inflammatory bowel diseases, obesity, and diabetes.

With projected growth in the human population over the coming decades, there is mounting pressure to find scientific solutions to feeding the world. We discuss strategies to upregulate ram fertility during the non-breeding season through artificial stimulation of reproductive onset.

This presentation explores the key regulators that determine whether OPC behaviour will help or hinder brain function.

T cells dynamically interact with multiple, distinct cellular subsets to determine effector and memory differentiation. Here, we have developed a platform to quantify cell location in 3D, to determine the spatial requirements that direct T cell fate.

Can mapping neural connectivity tell us how the brain works? A major goal of global brain research initiatives is the expensive and labour-intensive mapping of neural networks.