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Centenary Institute - Medical Research
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June 2019

Medical Research Seminar: Genetic cardiomyopathy

June 4 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

We are currently exploring the use of zebrafish in cardiovascular functional genomics to evaluate the effects of suspected pathogenic human gene variants on heart function. This will inform the analysis of whole genome sequencing data in patients with DCM and hopefully increase the yield of genetic testing.

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Medical Research Seminar: Innate immune cell function

June 11 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Immune cells have evolved clever mechanisms to dynamically reprogram their cellular metabolism to accommodate altered functional outputs. The immune system has also evolved similarly resourceful circadian mechanisms to anticipate microbial threats, and synchronise elevated immune responses with periods of activity when the threat of infection is greatest.

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Medical Research Seminar: Therapies for chronic respiratory diseases

June 18 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Respiratory diseases are major clinical issues. Ten-12% of Australians have asthma and chronic obstructive pulmonary disease (COPD) is the third commonest cause of death in the world. There are no effective treatments for severe asthma or COPD.

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Medical Research Seminar: Targeting glioblastoma stem cells

June 25 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Glioblastoma is the most aggressive primary brain tumour with median patient survival of 15 months. Given the extensive intratumoural molecular heterogeneity of glioblastomas and the lack of molecularly-targeted drugs that can permeate the blood-brain barrier, glioblastoma remains a major unmet medical need.

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July 2019

HRI & CI Medical Research Seminar: Thrombotic Disease

July 2 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Protein disulfide isomerase (PDI) is an essential component of in vivo clot formation. Using a high throughput screen, we identified rutin and isoquercetin as inhibitors of PDI.

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USyd & CI Medical Research Seminar: Lymphoid Cell

July 10 @ 1:00 pm - 2:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Prof Andrew McKenzie will present our recent development of multi-transcription factor, to enable the delineation of precursor states, and also show how the stromal niche can help maintain the microenvironment in adipose tissue.

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Medical Research Seminar: Fibrinolysis in Obesity

July 11 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

We have shown in lean mice that hepatocytes contribute substantially to basal plasma tPA and fibrinolysis and that hepatocyte tPA expression is repressed by DACH1. Moreover, liver DACH1 correlates with body mass index in humans and body weight in mice, suggesting a possible mechanism that limits tPA in obesity.

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Medical Research Seminar: Mucosal Macrophage Function

July 12 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

My work dissects the specific roles of macrophages in these regulatory processes, how their function is specifically tailored to their tissue of residence, and how macrophage function is regulated by the microbiota.

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Medical Research Seminar: Barrier Immune Responses

July 15 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Barrier surfaces such as the lung and intestine contain a huge number of immune cells that are poised to attack harmful micro-organisms, but must be tightly regulated to ignore innocuous environmental substances and commensal micro-organisms.

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Medical Research Seminar: Coagulation Disorders

July 18 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Significant progress has been made in our understanding of blood coagulation, but unknown genes contribute to the variable disease severity observed among patients with clotting disorders.

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