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Centenary Institute - Medical Research
Centenary Institute - Medical Research

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August 2019

Medical Research Seminar: Intravital imaging studies

August 27 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Neutrophils and macrophages are the front-line phagocytes involved in host defence. From live imaging of neutrophils and macrophages in zebrafish models, we have observed new aspects neutrophil morphology and function during infection and inflammation.

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September 2019

HRI & CI Medical Research Seminar: The Inflammatory Index

September 3 @ 12:00 pm - 1:00 pm
Charles Perkins Centre, Level 6 Seminar Room, University of Sydney
Camperdown, NSW 2006 Australia
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Inflammation is a double-edged weapon. When localized and moderate, it is beneficial – aiding the resolution of infections and healing. When excessive and systemic, it becomes a problem – host tissues may be damaged by its ‘friendly fire’. Mechanisms have thus evolved to keep inflammation under tight control. The seminar will describe what we know about how the Inflammation Reflex works and what may be its biological and medical significance.

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Medical Research Seminar: Data science and Stem Cell Biology

September 10 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

In this talk, I will first showcase a seminal work where integrative methods were used for discovering fundamental mechanisms in stem cells.

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Medical Research Seminar: Chronic conditions and infections

September 17 @ 8:00 am - 5:00 pm

Obesity and type 2 diabetes confer susceptibility to numerous different complications, including severe influenza virus infections. Here, I will discuss our latest research in our understanding of the role of both obesity and diabetes in severe influenza virus infections and what this means for influenza pandemic preparedness.

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October 2019

Medical Research Seminar: Inherited myopathies

October 1 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

For individuals with genetic disorders, obtaining a precise genetic diagnosis can be life changing. We have sought to find the genetic basis of disease for ~200 families with inherited neuromuscular disease (NMD)

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HRI & CI Medical Research Seminar: Cardiovascular Ageing

October 8 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Using a variety of genomics, epigenetic and proteomics approaches we have begun to dissect the mechanisms linked to inflammatory pathways. Identifying candidate pathways that may be amenable to manipulation in order to protect, delay or alleviate aspects of cardiovascular ageing.

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Medical Research Seminar: Watching the brain neural circuits

October 15 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

the larval zebrafish offers a perfect window into functioning neural circuits. We imaged the whole brain of zebrafish as they habituate to repeated looming stimuli.

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November 2019

HRI & CI Medical Research Seminar: Human Cardiac Organoids

November 5 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Our current research programs include understanding the mechanisms of cardiac biology and function so that we can come up with novel treatments for these patients. We are studying the core processes that improve heart function including maturation, interactions between different cell populations in the heart or outside of the heart and the role of metabolism.

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Medical Research Seminar: Signalling in Neurodegenerative Diseases

November 5 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

We have shown pronounced loss of the neuroprotective signalling lipid sphingosine 1-phosphate (S1P) in the pre-clinical phase of AD pathogenesis, and as a function of increasing age in the hippocampus of cognitively normal females.

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Research Seminar: Breeding in captivity to survive in the wild

November 19 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

How can we minimise harmful adaptive consequences when we breed animals in captivity? When do mechanisms that have evolved over thousands of generations, get overridden by human influences from just one generation to the next?

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