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Centenary Institute - Medical Research
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October 2019

Medical Research Seminar: Inherited myopathies

01/10/2019 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

For individuals with genetic disorders, obtaining a precise genetic diagnosis can be life changing. We have sought to find the genetic basis of disease for ~200 families with inherited neuromuscular disease (NMD)

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HRI & CI Medical Research Seminar: Cardiovascular Ageing

08/10/2019 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Using a variety of genomics, epigenetic and proteomics approaches we have begun to dissect the mechanisms linked to inflammatory pathways. Identifying candidate pathways that may be amenable to manipulation in order to protect, delay or alleviate aspects of cardiovascular ageing.

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Medical Research Seminar: Watching the brain neural circuits

15/10/2019 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

the larval zebrafish offers a perfect window into functioning neural circuits. We imaged the whole brain of zebrafish as they habituate to repeated looming stimuli.

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November 2019

HRI & CI Medical Research Seminar: Human Cardiac Organoids

05/11/2019 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Our current research programs include understanding the mechanisms of cardiac biology and function so that we can come up with novel treatments for these patients. We are studying the core processes that improve heart function including maturation, interactions between different cell populations in the heart or outside of the heart and the role of metabolism.

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Medical Research Seminar: Signalling in Neurodegenerative Diseases

05/11/2019 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

We have shown pronounced loss of the neuroprotective signalling lipid sphingosine 1-phosphate (S1P) in the pre-clinical phase of AD pathogenesis, and as a function of increasing age in the hippocampus of cognitively normal females.

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Research Seminar: Breeding in captivity to survive in the wild

19/11/2019 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

How can we minimise harmful adaptive consequences when we breed animals in captivity? When do mechanisms that have evolved over thousands of generations, get overridden by human influences from just one generation to the next?

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Medical Research Seminar: Treatment of Metabolic Diseases

26/11/2019 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Understanding mechanisms associated with exercise, obesity, type 2 diabetes and cancer and to develop novel drugs to treat lifestyle related diseases. The activation of the gp130 receptor complex is a useful target to treat metabolic diseases.

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December 2019

Medical Research Seminar: Transcriptional bursting

02/12/2019 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

The Ochiai Laboratory is working on the development of new experiments and technologies that combine genome editing, cell biology, and live-cell imaging technologies to measure transcriptional dynamics and to elucidate the molecular mechanisms of gene expression heterogeneity in mouse embryonic stem cells.

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Medical Research Seminar: CRISPR gene drive technology

10/12/2019 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Recent advances in genome editing technology suggest that CRISPR-Cas9 synthetic gene drives could be used as an alternative, humane strategy for invasive rodent population control. However, despite their potential, this has only been developed in a small number of species including flies, mosquitoes and yeast.

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Medical Research Seminar: Inflammation in Tuberculosis

16/12/2019 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Investigations of cellular determinants of Tuberculosis progression during experimental murine infection and employed in vitro models of granuloma. We unveiled myeloid-derived suppressor cells and platelets as novel regulators of TB pathogenesis.

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