Using a variety of genomics, epigenetic and proteomics approaches we have begun to dissect the mechanisms linked to inflammatory pathways. Identifying candidate pathways that may be amenable to manipulation in order to protect, delay or alleviate aspects of cardiovascular ageing.

the larval zebrafish offers a perfect window into functioning neural circuits. We imaged the whole brain of zebrafish as they habituate to repeated looming stimuli.

Our current research programs include understanding the mechanisms of cardiac biology and function so that we can come up with novel treatments for these patients. We are studying the core processes that improve heart function including maturation, interactions between different cell populations in the heart or outside of the heart and the role of metabolism.

We have shown pronounced loss of the neuroprotective signalling lipid sphingosine 1-phosphate (S1P) in the pre-clinical phase of AD pathogenesis, and as a function of increasing age in the hippocampus of cognitively normal females.

How can we minimise harmful adaptive consequences when we breed animals in captivity? When do mechanisms that have evolved over thousands of generations, get overridden by human influences from just one generation to the next?

Understanding mechanisms associated with exercise, obesity, type 2 diabetes and cancer and to develop novel drugs to treat lifestyle related diseases. The activation of the gp130 receptor complex is a useful target to treat metabolic diseases.

The Ochiai Laboratory is working on the development of new experiments and technologies that combine genome editing, cell biology, and live-cell imaging technologies to measure transcriptional dynamics and to elucidate the molecular mechanisms of gene expression heterogeneity in mouse embryonic stem cells.

Recent advances in genome editing technology suggest that CRISPR-Cas9 synthetic gene drives could be used as an alternative, humane strategy for invasive rodent population control. However, despite their potential, this has only been developed in a small number of species including flies, mosquitoes and yeast.