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May 2019

Medical Research Forum: International Day of Immunology – Asthma Research

May 2 @ 5:30 pm - 7:30 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Join us at Centenary Institute for this free public forum on Asthma to hear from our expert panel featuring research, clinical and patient perspectives.

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Medical Research Seminar: Detecting Atherosclerosis

May 7 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

n addition to Gemma’s seminar on atherosclerosis, she will give an update on the Australian Cardiovascular Alliance (ACvA) and the new Mission for Cardiovascular Health. Gemma is the current President of ACvA, which brings together the country’s major scientific societies, institutions, RACGP, industry and partners with the Heart Foundation for the advancement of heart, stroke and vascular disease research.

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Meeting: AFRAN Non-Tuberculous Mycobacterial

May 9 @ 9:30 am - 5:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

The Centenary Institute is hosting the Australia-France Non-Tuberculous Mycobacterial Research Meeting on Thursday, May 9, 2019. Registration for this meeting is free with the generous support of the Australian-French Association for Research and Innovation (AFRAN). The meeting will encompass biomedical and implementation science related to Non-Tuberculous Mycobacterial pathogens of importance to human and animal health.

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Medical Research Seminar: Multi-drug resistant mycobacterium

May 9 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Mycobacterium abscessus is a nontuberculous, multidrug resistant mycobacterium, causing severe lung infections. It possesses a lipid-rich cell wall comprising glycopeptidolipids (GPL) acting as major immunomodulators. M. abscessus presents smooth (S) and rough (R) morphotypes, determined by the presence or absence, respectively, of GPL, with the R variant being associated with more severe forms of the disease.

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Medical Research Seminar: Paternal Epigenetic Memory

May 14 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Two waves of DNA methylation reprogramming occur during mammalian embryogenesis; during preimplantation development and during primordial germ cell (PGC) formation. However, it is currently unclear how evolutionarily conserved these processes are. Here we characterize the DNA methylomes of zebrafish PGCs at four developmental stages and identify retention of paternal epigenetic memory, in stark contrast to the process in mammals.

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Medical Research Seminar: Post-translation in cancer

May 28 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

During my talk I will present our discoveries on the role of this post-translational modification in cancer and how it influences gene transcription deregulation. My group has also discovered the reader of the acetylation in humans and the underlying molecular mechanism of this process.

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June 2019

Medical Research Seminar: Genetic cardiomyopathy

June 4 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

We are currently exploring the use of zebrafish in cardiovascular functional genomics to evaluate the effects of suspected pathogenic human gene variants on heart function. This will inform the analysis of whole genome sequencing data in patients with DCM and hopefully increase the yield of genetic testing.

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Medical Research Seminar: Innate immune cell function

June 11 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Immune cells have evolved clever mechanisms to dynamically reprogram their cellular metabolism to accommodate altered functional outputs. The immune system has also evolved similarly resourceful circadian mechanisms to anticipate microbial threats, and synchronise elevated immune responses with periods of activity when the threat of infection is greatest.

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Medical Research Seminar: Therapies for chronic respiratory diseases

June 18 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Respiratory diseases are major clinical issues. Ten-12% of Australians have asthma and chronic obstructive pulmonary disease (COPD) is the third commonest cause of death in the world. There are no effective treatments for severe asthma or COPD.

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Medical Research Seminar: Targeting glioblastoma stem cells

June 25 @ 12:00 pm - 1:00 pm
Centenary Institute Lecture Theatre, Building 93, Royal Prince Alfred Hospital Camperdown, New South Wales 2050 Australia

Glioblastoma is the most aggressive primary brain tumour with median patient survival of 15 months. Given the extensive intratumoural molecular heterogeneity of glioblastomas and the lack of molecularly-targeted drugs that can permeate the blood-brain barrier, glioblastoma remains a major unmet medical need.

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