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    Centenary Institute > Laboratories > Cancer and Gene Regulation

Cancer and Gene Regulation

Gene regulation is frequently dysregulated in cancer. During cancer initiation, transcription factors can exhibit somatic mutations including point mutations in regulatory domains or undergo copy number variations due to genetic deletion.

The essential chromatin organising protein and tumour suppressor gene CTCF is central to our research focus. Mutations in CTCF occur frequently in endometrial and breast cancers, as well as leukaemia. We are functionally characterising mutations in CTCF and their impact on DNA binding, protein-protein interactions, chromatin organisation and cell growth characteristics. Our research is revealing new insights into the molecular pathogenesis of cancer initiation and progression.

To understand the impact of somatic mutations on key regulatory genes in cancer, we are performing cell growth and DNA-binding assays, loss- or gain-of-function studies, examining protein-protein interactions and transcriptomics.

Our expertise in molecular modelling of somatic mutations on existing protein structures or by developing homology models has enabled us to examine structure-function relationships in cancer.

Furthermore, our mouse models of those genetic lesions that result in genetic haploinsufficiency are helping us to understand cancer causation in various tissues and organs and their impact on normal gene regulatory homeostasis.

 

Dr Charles Bailey

Head, Cancer and Gene Regulation Laboratory

Themes

  • Cancer

    Cancer

Head

  • Dr Charles Bailey

    Head, Cancer and Gene Regulation Laboratory

    Phone number Phone Number 61 2 9565 6171

    Email Email c.bailey@centenary.org.au

Programs

  • Gene and Stem Cell Therapy Program

Topics

  • Chronic diseases ,

Expertise

  • Genomics ,

Publications

Recent publications

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For access to all Publications via Pub Med.

To understand the impact of somatic mutations on key regulatory genes in cancer, we are performing cell growth and DNA-binding assays, loss- or gain-of-function studies, examining protein-protein interactions and transcriptomics.

Our expertise in molecular modelling of somatic mutations on existing protein structures or by developing homology models has enabled us to examine structure-function relationships in cancer.

Furthermore, our mouse models of those genetic lesions that result in genetic haploinsufficiency are helping us to understand cancer causation in various tissues and organs and their impact on normal gene regulatory homeostasis.

 

Dr Charles Bailey

Head, Cancer and Gene Regulation Laboratory

News

  • Inflammation presentation awarded

    Dr Joyce Chiu from the ACRF Centenary Cancer Research Centre has won an Oral Communication Award for her talk given at the 15th World Congress on Inflammation, held in Rome, June 2022.
    Date 01 Jul 2022
  • Meet Dr Annalicia Vaughan

    A medical researcher at the Centenary UTS Centre for Inflammation, Dr Annalicia Vaughan specialises in the gut-lung axis and its role in lung and respiratory diseases.
    Date 28 Jun 2022
    Dr Vaughan Dr Vaughan
  • The Centenary Institute is excited to join the Sydney Biomedical Accelerator (SBA) as primary medical research partner

    The Centenary Institute welcomes the NSW Government’s commitment to fund a new biomedical complex in Camperdown. The Chair of the Centenary Institute Board, Joseph Carrozzi AM, and its Executive Director, Professor Mathew Vadas AO, are thrilled that a biomedical complex, the Sydney Biomedical Accelerator (SBA), will now be a reality.
    Date 17 Jun 2022
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© 2017 Centenary Institute of Cancer Medicine and Cell Biology.

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