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    Centenary Institute > Cancer and Gene Regulation Laboratory

Cancer and Gene Regulation Laboratory

Gene regulation is frequently dysregulated in cancer. During cancer initiation, transcription factors can exhibit somatic mutations including point mutations in regulatory domains or undergo copy number variations due to genetic deletion.

The essential chromatin organising protein and tumour suppressor gene CTCF is central to our research focus. Mutations in CTCF occur frequently in endometrial and breast cancers, as well as leukaemia. We are functionally characterising mutations in CTCF and their impact on DNA binding, protein-protein interactions, chromatin organisation and cell growth characteristics. Our research is revealing new insights into the molecular pathogenesis of cancer initiation and progression.

To understand the impact of somatic mutations on key regulatory genes in cancer, we are performing cell growth and DNA-binding assays, loss- or gain-of-function studies, examining protein-protein interactions and transcriptomics.

Our expertise in molecular modelling of somatic mutations on existing protein structures or by developing homology models has enabled us to examine structure-function relationships in cancer.

Furthermore, our mouse models of those genetic lesions that result in genetic haploinsufficiency are helping us to understand cancer causation in various tissues and organs and their impact on normal gene regulatory homeostasis.

 

Dr Charles Bailey

Head, Cancer and Gene Regulation Laboratory

Themes

  • Cancer

    Cancer

Head

  • Dr Charles Bailey

    Head, Cancer and Gene Regulation Laboratory

    Phone number Phone Number 61 2 9565 6171

    Email Email c.bailey@centenary.org.au

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  • Gene and Stem Cell Therapy Program

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To understand the impact of somatic mutations on key regulatory genes in cancer, we are performing cell growth and DNA-binding assays, loss- or gain-of-function studies, examining protein-protein interactions and transcriptomics.

Our expertise in molecular modelling of somatic mutations on existing protein structures or by developing homology models has enabled us to examine structure-function relationships in cancer.

Furthermore, our mouse models of those genetic lesions that result in genetic haploinsufficiency are helping us to understand cancer causation in various tissues and organs and their impact on normal gene regulatory homeostasis.

 

Dr Charles Bailey

Head, Cancer and Gene Regulation Laboratory

News

  • Metastatic cancer research boosted

    Dr Dannel Yeo from the Centenary Institute and Clinical Associate Professor Kate Mahon from Chris O’Brien Lifehouse, have been awarded an inaugural Sydney Cancer Partners Translational Fellowship.
    Date 03 Mar 2023
  • The Year That Made Me: Professor John Rasko

    Professor John Rasko AO, Head of the Gene and Stem Cell Therapy Program at the Centenary Institute has featured on the popular Radio National show Sunday Extra in the segment called ‘The Year That Made Me’.
    Date 21 Feb 2023
  • Top abstract prize for gene therapy research

    Professor John Rasko AO and team have received the top scoring abstract award at the 16th Annual Congress of the European Association for Haemophilia and Allied Disorders in Manchester.
    Date 15 Feb 2023
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© 2017 Centenary Institute of Cancer Medicine and Cell Biology.

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