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    Centenary Institute > Computational BioMedicine Laboratory

Computational BioMedicine Laboratory

In the Computational BioMedicine lab, we develop integrative workflows combining various computational disciplines with experimentation to address questions around non-coding RNAs, post-transcriptional gene regulation and cancer biology.

Using machine learning, mathematical modelling, and molecular dynamics simulations we investigate mechanisms of post-transcriptional gene regulation. We found, for example, that synergistic target regulation by microRNAs is a widespread phenomenon of post-transcriptional gene regulation – a mechanisms that can be exploited to sensitize aggressive tumour cells to chemotherapy.

We develop multi-omics data analysis pipelines to investigate patterns of alternative splicing and other forms of gene regulation in normal biology and in various cancers. We identified intron retention as a well conserved form of alternative splicing that mediates cell-specific gene regulation. Aberrant intron retention has been described in multiple human cancers. We aim to identify regulators and consequences of intron retention as well as cross-talk with other forms of post-transcriptional gene regulation.

Head

Dr Ulf Schmitz

Visiting researcher

Themes

  • Cancer

    Cancer

Head

  • Dr Ulf Schmitz

    Visiting researcher

    Phone number Phone Number 02 9565 6209

    Email Email u.schmitz@centenary.org.au

Programs

  • Gene and Stem Cell Therapy Program

Research Fields

  • Bioinformatics

Topics

  • Chronic diseases ,

Expertise

  • Bioinformatics ,

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Using machine learning, mathematical modelling, and molecular dynamics simulations we investigate mechanisms of post-transcriptional gene regulation. We found, for example, that synergistic target regulation by microRNAs is a widespread phenomenon of post-transcriptional gene regulation – a mechanisms that can be exploited to sensitize aggressive tumour cells to chemotherapy.

We develop multi-omics data analysis pipelines to investigate patterns of alternative splicing and other forms of gene regulation in normal biology and in various cancers. We identified intron retention as a well conserved form of alternative splicing that mediates cell-specific gene regulation. Aberrant intron retention has been described in multiple human cancers. We aim to identify regulators and consequences of intron retention as well as cross-talk with other forms of post-transcriptional gene regulation.

Head

Dr Ulf Schmitz

Visiting researcher

News

  • Meet Dr Ulf Schmitz

    Hi I’m Dr Ulf Schmitz and I lead the Computational BioMedicine Research Laboratory at Centenary.
    Date 10 Sep 2020
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© 2017 Centenary Institute of Cancer Medicine and Cell Biology.

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