Directed Evolution Laboratory
Working with international collaborators, we have recently identified a new trigger for cardiac regeneration. In humans, this regenerative pathway is not properly engaged after a heart attack preventing a full recovery. We are applying our expertise in protein evolution (the engineering of new proteins with new traits) to increase the potency of this regenerative trigger to use as a therapeutic to improve outcomes after heart attack.
Heart disease
Cardiovascular disease (CVD) affects more than four million Australians and causes one in four deaths, with disproportionately worse outcomes in Aboriginal and Torres Strait Islanders. More treatment options are urgently needed to improve outcomes for those with CVD.
We develop and apply novel Directed Evolution platforms that couple mutagenesis, selection and next-generation sequencing to identify proteins with desirable properties. In the context of CVD we aim to specifically trigger regeneration of the heart to replace the cardiac muscle that is damaged by a heart attack.
Australian
Anzac Research Institute
Garvan Institute of Medical Research
Hunter Medical Research Institute
James Cook University
Macquarie University
Menzies Research Institute, University of Tasmania
Monash Children’s Hospital
Monash University
St Vincent’s Hospital Sydney
University of Queensland
University of Newcastle
University of New South Wales Sydney
University of Sydney
Victor Chang Cardiac Research Institute
International
Institut Pasteur, France
Le Reseau International Des Instituts Pasteur RIIP, France
Max Planck Society, Germany
National Cerebral and Cardiovascular Center Research Institute, Japan
Heart disease
Cardiovascular disease (CVD) affects more than four million Australians and causes one in four deaths, with disproportionately worse outcomes in Aboriginal and Torres Strait Islanders. More treatment options are urgently needed to improve outcomes for those with CVD.
We develop and apply novel Directed Evolution platforms that couple mutagenesis, selection and next-generation sequencing to identify proteins with desirable properties. In the context of CVD we aim to specifically trigger regeneration of the heart to replace the cardiac muscle that is damaged by a heart attack.
Australian
Anzac Research Institute
Garvan Institute of Medical Research
Hunter Medical Research Institute
James Cook University
Macquarie University
Menzies Research Institute, University of Tasmania
Monash Children’s Hospital
Monash University
St Vincent’s Hospital Sydney
University of Queensland
University of Newcastle
University of New South Wales Sydney
University of Sydney
Victor Chang Cardiac Research Institute
International
Institut Pasteur, France
Le Reseau International Des Instituts Pasteur RIIP, France
Max Planck Society, Germany
National Cerebral and Cardiovascular Center Research Institute, Japan
