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    Centenary Institute > Lipid Cell Biology Laboratory

Lipid Cell Biology Laboratory

Dr Yanfei Jacob Qi
Our research is focused on the lipid metabolic causes of chronic human diseases, including diabetes, fatty liver, cancer and atherosclerosis.

The Lipid Cell Biology Laboratory is currently investigating the following projects:

1. Liver disease

The liver is the primary metabolic organ in our body. Abnormal fat deposition in the liver causes a series of conditions, including insulin resistance, fatty liver, liver fibrosis and liver cancer. Medical research on these liver diseases plays a crucial role in improving the quality of life for people with chronic illness and extending survival time for those with the fatal disease. At the forefront of medical research, Lipid Cell Biology Laboratory is focused on the study of sphingolipids, a class of essential fat products, in the liver. Dr Qi and his colleagues aim to identify key components of sphingolipids, as novel druggable targets and early diagnostic biomarkers of liver diseases.

2. Cardiovascular disease

Atherosclerosis is a chronic condition in which arteries harden and narrow due to a build-up of fatty plaque on the arterial wall. Although the use of blood cholesterol-lowering medications can be successful in halting or reducing this plaque build-up, atherosclerosis remains the leading cause of cardiovascular disease-related death worldwide. This problem needs a new solution. In addition to levels of risk factors in the blood, Dr Qi believes that how blood vessel senses the deleterious environment may also determine the outcome of atherosclerosis. Lipid Cell Biology Laboratory is now studying how fat products within blood vessel cells affect vascular fitness and disease progression. This project will open a window for the development of a new class of drugs, targeting blood vessels to treat atherosclerosis.

We are employing tissue-specific knockout mice, human samples and cutting-edge technologies, such as desorption electrospray ionization mass spectrometric imaging (DESI-MSI), real-time single molecule imaging and lipidomics to achieve a good understanding of disease development temporospatially. In addition, we are also exploiting molecular and cell biology techniques to address in-depth mechanisms of disease initiation and progression.

Dr Yanfei (Jacob) Qi

Head, Lipid Cell Biology Laboratory

Themes

  • Cardiovascular

    Cardiovascular
  • Inflammation

    Inflammation

Head

  • Dr Yanfei (Jacob) Qi

    Head, Lipid Cell Biology Laboratory

    Phone number Phone Number +612 8627 6045

    Email Email j.qi@centenary.org.au

Programs

  • Vascular Biology Program

Research Fields

  • Diabetes

  • Liver disease

Topics

  • Chronic diseases ,

Publications

Recent publications

Search amongst our repository

all publications

For access to all Publications via Pub Med.

We are employing tissue-specific knockout mice, human samples and cutting-edge technologies, such as desorption electrospray ionization mass spectrometric imaging (DESI-MSI), real-time single molecule imaging and lipidomics to achieve a good understanding of disease development temporospatially. In addition, we are also exploiting molecular and cell biology techniques to address in-depth mechanisms of disease initiation and progression.

Dr Yanfei (Jacob) Qi

Head, Lipid Cell Biology Laboratory

News

  • Orchid extract holds hope for prostate cancer treatment

    Research led by the Centenary Institute has found that a compound extracted from a commonly cultivated orchid could be a potential new treatment option for prostate cancer.
    Date 19 Sep 2021
  • Enzyme insight could lead to new diabetes treatment

    Research led by the Centenary Institute has discovered that the lack of an enzyme in the liver called sphingosine kinase 2 (SphK2) results in pronounced insulin resistance and glucose intolerance, both symptoms of early stage type 2 diabetes.
    Date 13 Sep 2020
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