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    Centenary Institute > Epigenetics of Melanoma Program

Epigenetics of Melanoma Program

Dr Jess Tiffen
The Epigenetics of Melanoma Program seeks to understand how deregulation of epigenetic modifiers can potentially govern all hallmarks of cancer. Using cutting edge techniques such as CRISPR, high throughput drug screening and mouse models, we seek to identify new targets for potential treatments.

Working closely with collaborators we will look to identify drugs that can be rapidly screened in the laboratory using our extensive pre-clinical in vitro and in vivo melanoma models. This will allow us to study tumour growth, metastases and resistance to therapy.

Our ultimate goal is to apply the knowledge we have gained through this current work in melanoma and expand into other cancer areas which have poor prognosis, such as cancers of the lung, pancreas and brain.

The Epigenetics of Melanoma Program works to understand how epigenetic regulators such as histone modifications drive melanoma progression, immune evasion and response to therapy.

Projects

  • The role of histone and chromatin modifier’s in melanoma progression and treatment resistance.
  • Identifying novel epigenetic regulators of targeted therapy and immunotherapy resistance.
  • Investigating sex differences in X-linked epigenetic regulators of melanoma.

Dr Jessamy Tiffen

Head, Epigenetics of Melanoma Program

Themes

  • Cancer

    Cancer

Head

  • Dr Jessamy Tiffen

    Head, Epigenetics of Melanoma Program

    Phone number Phone Number +612 9565 6100

    Email Email j.tiffen@centenary.org.au

Research Fields

  • Melanoma

Topics

  • Chronic diseases ,

Expertise

  • Epigenetics ,

Publications

Recent publications

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The Epigenetics of Melanoma Program works to understand how epigenetic regulators such as histone modifications drive melanoma progression, immune evasion and response to therapy.

Projects

  • The role of histone and chromatin modifier’s in melanoma progression and treatment resistance.
  • Identifying novel epigenetic regulators of targeted therapy and immunotherapy resistance.
  • Investigating sex differences in X-linked epigenetic regulators of melanoma.

Dr Jessamy Tiffen

Head, Epigenetics of Melanoma Program

News

  • Dr Jessamy Tiffen promoted to Faculty at Centenary

    Dr Jessamy Tiffen has been promoted to the Scientific Faculty at the Centenary Institute where she will be a part of the senior science leadership team.
    Date 22 Aug 2022
  • Over $4 million in grants to boost cancer research at the Centenary Institute

    Two Centenary Institute scientists have been awarded grants totalling $4.3 million from the Cancer Institute NSW to undertake critical cancer related medical research.
    Date 03 Dec 2021
  • Boost to world-class melanoma research

    World-class research into melanoma, the deadliest form of skin cancer, has been boosted with Dr Jessamy Tiffen, Head of the Centenary Institute's Melanoma Epigenetics Laboratory, receiving a $447,000 project grant from Cancer Council NSW.
    Date 24 May 2021
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