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    Centenary Institute > Liver Injury and Cancer Program

Liver Injury and Cancer Program

Prof Geoff McCaughan
Our work is devoted to understanding pathways at the cellular and molecular levels that drive liver injury and cancer. These pathways may then be identified as targets to modulate these processes or be used for diagnosis and staging of liver disease and cancer.

Liver diseases are caused by chronic inflammation. They are driven by many factors including viruses, autoimmune processes, genetic diseases and toxins such as alcohol.

We initially used human liver samples to screen for molecules that we up regulated. Since then we have taken some of these molecules and manipulated them in experimental models. This has allowed us to test whether these molecules actually play a role in causing liver injury.

According to The Australian Liver Association, liver disease now affects over six million Australians and has an annual cost burden of $50.7 billion.

Liver disease is responsible for one quarter of all organ transplants and if left untreated, results in liver cancer – our fastest growing form of cancer in Australia.

The increasing prevalence of all forms of liver disease, but in particular fatty liver disease with concurrent diabetes, is a huge burden. Our research stems from test tubes, to animal models, human models and clinical trials.

Head

Professor Geoff McCaughan

Head of Liver Injury and Cancer Program

Themes

  • Cancer

    Cancer

Head

  • Professor Geoff McCaughan

    Head of Liver Injury and Cancer Program

    Phone number Phone Number +61 2 9565 6125

    Email Email g.mccaughan@centenary.org.au

Research Fields

  • Liver disease

Topics

  • Chronic diseases ,

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According to The Australian Liver Association, liver disease now affects over six million Australians and has an annual cost burden of $50.7 billion.

Liver disease is responsible for one quarter of all organ transplants and if left untreated, results in liver cancer – our fastest growing form of cancer in Australia.

The increasing prevalence of all forms of liver disease, but in particular fatty liver disease with concurrent diabetes, is a huge burden. Our research stems from test tubes, to animal models, human models and clinical trials.

Head

Professor Geoff McCaughan

Head of Liver Injury and Cancer Program

News

  • Understanding unexplained heart failure in patients with liver cirrhosis

    The Centenary Institute’s Dr Madeleine Gill has today received a National Health and Medical Research Council (NHMRC) postgraduate scholarships grant to continue her research into understanding unexplained heart failure in patients with liver cirrhosis. Cirrhotic cardiomyopathy affects approximately 50 per cent of patients with cirrhosis and can be a barrier to liver transplantation and is ...
    Date 13 Jan 2022
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© 2017 Centenary Institute of Cancer Medicine and Cell Biology.

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