Home > Inflammation
Centenary Institute - Medical Research
Centenary Institute - Medical Research

Centenary Institute Oration now available for download

Catch-up on the recent Centenary Institute Oration – delivered by science journalist and health broadcaster Dr Michael Mosley.

Dr Mosley spoke on the topic of inflammation, obesity and depression.

Over the course of an hour, Dr Mosley emphasised the point that intermittent fasting, exercising and a switch to a Mediterranean style (anti inflammatory) diet were all helpful in preventing disease.

The talk can be downloaded now from the Radio National web site – please click here.

Sea sponge could be key in fight against TB

An Australian sea sponge could hold the key to successfully combatting the deadly disease tuberculosis (TB), a new study from the Centenary Institute and the University of Sydney suggests.

Reported in the journal ‘Nature Scientific Reports’, the sea sponge was found to contain an exceptionally potent anti-bacterial agent able to inhibit Mycobacterium tuberculosis–the bacteria that causes TB in humans.

Every year more than 10 million people fall ill with TB and 1.8 million die from the disease. The new finding has the potential to open-up a new avenue of research to target what is the world’s top infectious disease killer.

“TB is a major global health problem and our battle against this resilient and deadly disease is incredibly difficult,” said the study’s lead author, Dr Diana Quan, a researcher affiliated with the Centenary Institute and the Microbial Pathogenesis and Immunity Group led by Professor Jamie Triccas at the University of Sydney.

“Effective antibiotics for TB are difficult to develop, there are constant issues with new drug-resistant TB strains and our current treatment approach for TB is both lengthy and complicated,” she said. “There is an urgent need for new drugs and antibiotics which can shorten and simplify TB treatment in order to combat this burgeoning TB pandemic.”

In the reported study, a sea sponge from the Tedaniidae family was examined by Dr Quan and found to yield compounds that displayed strong inhibitory potency against TB and also importantly, against drug-resistant strains of the disease. Following analysis, the active component from the sponge was identified as bengamide B which was also found to be non-toxic when tested against human cell lines.

“This is an extremely exciting finding,” said Dr Quan. “Bengamide B shows significant potential as a new class of compound for the treatment of tuberculosis and also importantly, for the treatment of drug-resistant TB which is an ever increasing obstacle to TB eradication around the world.”

The sea sponge was harvested off the Queensland coast and was one of approximately 1,500 different marine samples tested by Dr Quan for possible effectiveness against TB over the course of a three year program.

Read the full media release here.

ABC news interview with Dr Quan

Dr Michael Mosley delivers Centenary Institute Oration

Internationally recognised science journalist and health broadcaster Dr Michael Mosley has delivered the 2019 ‘Centenary Institute Oration’ to a crowd of more than 1000 researchers and members of the public at Sydney’s International Convention Centre.

The Oration, developed by the Centenary Institute to help inform the community as to the exciting health advances that are taking place via research, was timed to coincide with the World Congress on Inflammation which was also sponsored by the Institute.

In keeping with the theme of Inflammation (which underlies many acute and chronic conditions and which drives the initiation and progression of cancer and cardiovascular disease), Dr Mosley spoke on the topic of ‘Inflammation, obesity and depression’.

Over the course of an hour, Dr Mosley made the point that science is now supporting new ways to treat inflammation driven conditions. Emphasised were intermittent fasting, exercising and a switch to a Mediterranean style (anti inflammatory) diet.

The Oration was followed by an interactive Q&A session with the audience. Many were eager to find out more as to how a combination of healthy eating and lifestyle choices could potentially help improve lives.

The Centenary Institute wishes to thank Dr Mosley for his support of the Oration and also for his ongoing efforts in helping promote the latest in health-related research to the wider community.

The talk can be downloaded now from the Radio National web site – please click here.

AFR article – featuring Prof Mathew Vadas and Prof Jennifer Gamble

The Australian Financial Review has written about the ground-breaking medial research being carried out by the Centenary Institute’s Prof Mathew Vadas and Prof Jennifer Gamble.

Click here to read more about the endothelium and its involvement in inflammation which is now being viewed as the driver of most chronic disease.

Centenary Institute research boost with NHMRC Investigator Grants

Professor Philip Hansbro, Deputy Director at the Centenary Institute and Professor John Rasko AO, Head of the Centenary Institute’s Gene and Stem Cell Therapy Program have both been awarded prestigious National Health and Medical Research Council (NHMRC) Investigator Grants. The Investigator Grants scheme is one of the NHMRC’s new flagship funding arrangements supporting outstanding health and medical researchers.

Professor Philip Hansbro’s funding will support further research into the development of new preventions and treatments for chronic respiratory diseases.

“Respiratory diseases are among the leading causes of all deaths world-wide,” says Professor Hansbro.

“This grant will fund our research into developing a comprehensive ‘molecular map’ for specific respiratory diseases including Chronic Obstructive Pulmonary Disease (COPD), lung cancer and severe asthma. This will increase our knowledge of how these diseases develop and progress, providing us with new opportunities to attempt treatments and cures.”

Professor John Rasko AO, Head of the Centenary Institute’s Gene and Stem Cell Therapy Program and Head of Department, Cell & Molecular Therapies at Royal Prince Alfred Hospital will receive funding for his research focused on driving clinical cell and gene therapy in Australia.

“Harnessing the power of our body’s own cells and genetic therapies, we are witnessing a medical revolution in curing serious diseases including hereditary bleeding and anaemia as well as specific forms of cancer. This new federal funding will facilitate our internationally acclaimed basic and clinical research Program designed to improve the health of Australians”, says Professor Rasko.

Read the full media release here.

Dr Michael Mosley to deliver ‘Centenary Institute Oration’ on obesity and depression

Dr Michael Mosley, British physician, science journalist and documentary maker will deliver a free public talk at the 14th World Congress on Inflammation, in Sydney on Monday 16th September 2019.

Internationally recognised for his television shows and his best-selling books (including the 5+2 diet), Dr Mosley will deliver the Centenary Institute Oration, ‘Inflammation: a new approach to obesity and depression’.

Organised and hosted by leading medical research organisation the Centenary Institute, the Oration will be free for members of the general public to attend. They can expect an entertaining and informative talk from Dr Mosley that makes the human body, science and research accessible to all.

“Obesity and depression are widespread in Australia and it appears as if there is a common underlying mechanism involved: inflammation” explains Dr Michael Mosley. “I’m very much looking forward to talking about these very significant health issues which affect and impact so many Australians today.”

Read the full media release here.

Inflammation Fact Sheet

Think you know about inflammation? Think again. Redness, swelling, muscle aches…that’s not even the half of it. Chronic inflammation is a key driver of diseases, such as cancer, cardiovascular disease and autoimmune diseases. Read more.

Cellular Inflammation: The Secret Killer

We now know that inflammation plays a crucial role in our immune system however research has shown that it plays a role at a cellular level in the development of disease.

We concentrate our research on inflammation mechanism. It underlies a number of prevalent acute and chronic conditions, as well it drives the initiation and progression of cancer and cardiovascular disease.

Inflammation research: why it matters

Diabetes

A third of all diabetics will suffer from vision loss and potential blindness during their lifetime. This condition is caused by inflammation in the retina blood vessels.

Centenary’s Impact 

We have developed an exciting new drug which has the potential to mend the damaged blood vessels and prevent loss of sight.

Read more about our diabetes work here.

Alzheimer’s Disease

Alzheimer’s disease is the leading cause of dementia and the second leading cause of death in Australia. Evidence is mounting that inflammation plays a key role.

Centenary’s Impact 

We are investigating new ways to target and treat debilitating diseases such as Alzheimer’s disease, by focusing our research on inflammation in the brain.

Read more about our Alzheimer’s disease work here.

Respiratory Diseases

Two of the top five killers of Australians are diseases of the lungs and airways. Inflammation appears to play a major role.

Centenary’s Impact 

We are identifying new ways to tackle inflammation by developing comprehensive ‘molecular maps’ for Chronic Obstructive Pulmonary Disease, lung cancer and asthma. 

Read more about our Asthma work here.

Inflammation Research Foundation – Cellular Inflammation: The Secret Killer (Article).

Metaflammation

Metaflammation is a new term that refers to low levels of inflammation throughout the body.

Your body use the essential repair process of inflammation to heal the body. When you have a full blown infection your levels are very high. Metaflammation is different. It is much much lower but constant.

This new aspect of inflammation has come to light, its connection with chronic metabolic diseases, like obesity and diabetes. One of the reasons this link is really important is that we are able to control with small molecule or biological therapeutics some aspects of inflammation. This approach might become really useful in treating some diseases that were thought to be diet or environment influenced and may become a devastating problem in the future.

Inflammation research: why it matters

Diabetes

A third of all diabetics will suffer from vision loss and potential blindness during their lifetime. This condition is caused by inflammation in the retina blood vessels.

Centenary’s Impact 

We have developed an exciting new drug which has the potential to mend the damaged blood vessels and prevent loss of sight.

Read more about our diabetes work here.

Centenary Institute scientists are working on many aspects of inflammation, including metaflammation. For more details on our research approaches see here.