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Centenary Institute - Medical Research
Centenary Institute - Medical Research

Improved insight into tumour growth

The Centenary Institute has collaborated with fellow medical research institute, the Hudson Institute in Victoria, to develop a novel model system for accurately monitoring tumour stage and immune cells involvement.

Head of Centenary’s Liver Enzymes in Metabolism and Inflammation Program, Professor Mark Gorrell, was involved in the research project.

Ovarian cancer develops slowly and the immune system is crucial in controlling the tumour. In this particular study, the researchers modified ovarian cancer cells so they glowed in a way that can be seen in live laboratory mice models – enabling counts of tumour cells and immune cell subsets when each tumour is removed.

This system has allowed the researchers to learn new information on tumour growth, as well as discover which immune cells are in the tumour.

The researchers plan to apply the model to other cancers, including liver cancer.

Read the full study online in scientific journal Cancers.

Learn more about how Professor Gorrell’s team at Centenary is working to help develop a new liver disease test.

New knowledge about a potential pathway for cancer therapies

Centenary Institute scientists have discovered dozens of new likely targets for a particular enzyme (FAP) that is within most tumours; paving the way for the future development of safer and more effective cancer therapies, including liver, lung, skin, colorectal and pancreatic cancers.

Instead of affecting and interacting with just collagen, the researchers have used new technologies to identify 37 molecules which FAP likely modifies.

Co-lead author, Dr Hui Emma Zhang from the Centenary Institute, says this study not only reaffirms the value of FAP in cancer research, but it also provides new avenues through which scientists can target tumour growth.

“Given FAP is fairly unique to damaged cells when compared to healthy cells, the findings from our research will enhance the initial identification and imaging of tumours, as well as provide a safer and more targeted pathway through which anti-cancer therapies can be delivered,” says Dr Zhang.

See the full media release.

Read Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics in Molecular and Cellular Proteomics.

Pictured: A human liver tumour (large pale cells) surrounding a peninsular of stromal cells (dense blue), with FAP molecules stained dark brown.

Metaflammation

Inflammation is all good. It is an essential repair process that heals the body, defends it from infection.

However it is also a very powerful process, which when left unchecked causes many diseases directly (like arthritis) but also indirectly (like cancer and vascular disaeses).

A new aspect of inflammation is coming to light, its connection with chronic metabolic diseases, like obesity and diabetes.

In fact its has been given a new name ‘Metaflammation’. 

http://www.nature.com/nature/journal/v542/n7640/full/nature21363.html

One of the reasons this link is really important is that we are able to control with small molecule or biological therapeuti s some aspects of inflammation and thus this approach might become really useful in treating some diseases that were thought to be diet or environment influenced..and are looking to become a devastating problem in the future.

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