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Centenary Institute

Dr Kieran English has won the top spot in Centenary’s ‘When Art Meets Science’ exhibition with for his portrayal of T cells, an important part of the immune system.

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Your support will help save more lives

Your special gift of today represents more than a donation: it is an investment in the future health and happiness of all Australian families.

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Pivotal role of TLR7 protein revealed in lung disease

Researchers have revealed that the protein Toll-like receptor 7 (TLR7), usually associated with antiviral defence in the body, surprisingly, exacerbates lung conditions.

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Centenary Symposium 2023

We brought together the entire Centenary Institute to reflect on the achievements and successes of the past year while showcasing the ground-breaking research occurring at the Institute.

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The Centenary UTS Centre for Inflammation scholarship openings

The Centre currently has openings for PhD Scholarships in two project areas.

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News and Events

  • New technology, ‘Invasion-Block’, targets melanoma spread

    Research conducted at the Centenary Institute has given rise to a ground-breaking tool called 'Invasion-Block' that can identify drugs capable of halting the spread of cancer cells. The pioneering development could lead to better treatments for melanoma, the most dangerous form of skin cancer.
    News Type: Media release
    Date 22 Nov 2023
  • Pivotal role of TLR7 protein revealed in lung disease

    The discovery, led by the Centenary Institute and the University of Technology Sydney, could advance treatments for COPD, a lung condition that makes it difficult to breathe due to narrowed airways and damaged lung tissue. COPD is often caused by smoking or exposure to irritants. Lead study researcher, Dr Gang Liu at the Centenary UTS ...
    News Type: Media release
    Date 16 Nov 2023
  • Centenary symposium celebrates year’s achievements

    The 2023 Centenary Celebration Symposium has taken place, bringing the entire Centenary Institute together, to reflect on achievements and successes of the past year while showcasing the ground-breaking research occurring at the Institute.
    News Type: Institute
    Date 10 Nov 2023
  • ARC grant to fuel research into cellular ageing

    Centenary Institute researchers have been awarded an Australian Research Council (ARC) Discovery Project grant worth $709,714 to advance understanding of the intricate mechanisms underlying cellular ageing.
    News Type: Media release
    Date 03 Nov 2023
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We currently have openings for honors, masters and We currently have openings for honors, masters and PhD students in six project areas across our Cancer Innovations, Inflammation and Infection & Immunity Centres. Scholarships are also available for the right candidates! To learn more and to apply go to 'Student Openings' at link in bio.

#honors #phd #masters #centenary #centenaryinstitute #studentopportunities #sciencegraduates
New cancer discovery! Research conducted at the New cancer discovery! 

Research conducted at the Centenary Institute has given rise to a ground-breaking screening tool called 'Invasion-Block' that can identify drugs capable of halting the spread of cancer cells. The pioneering development could lead to better treatments for melanoma, the most dangerous form of skin cancer.

Dr Shweta Tikoo, senior study researcher affiliated with both the Centenary Institute and the Department of Dermatology, Medical University of Vienna said that melanoma is an extremely challenging disease.

“Melanoma is a tough opponent, often spreading rapidly and making it difficult to treat. The key to finding better treatments lies in drug discovery and this is where the ‘Invasion-Block’ tool plays a pivotal role,” said Dr Tikoo.

Excitingly for the researchers, ‘Invasion Block’ revealed that drugs that blocked a class of enzymes – known as Abl/Src, PKC, PI3K, and ATM kinases – made melanoma cells much less able to invade other tissues.

“This suggests these enzymes may hold the key to finding treatments that can help curb the spread of melanoma,” said Dr Dajiang Guo, the first author of the study, currently a postdoctoral researcher at the Weill Cornell Medicine.

For more, please click the link in our bio.

#cancer #melanoma #medical #research #science #metastasis #disease #screening
New Discovery! Our researchers have revealed tha New Discovery! 

Our researchers have revealed that the protein TLR7, usually associated with antiviral defence in the body, surprisingly, exacerbates lung conditions such as chronic obstructive pulmonary disease (COPD), also known as emphysema.

The discovery, led by the Centenary Institute and the University of Technology Sydney, could advance treatments for COPD, a lung condition that makes it difficult to breathe due to narrowed airways and damaged lung tissue.

The researchers said that TLR7 unexpectedly worsens lung problems such as COPD by working with mast cells (a type of immune cell).

They believe that blocking TLR7 with targeted drugs could be a promising new therapeutic approach for COPD, which currently has no cure.

Pictured: Lead study researcher, Dr Gang Liu, Centenary UTS Centre for Inflammation.
 
For more, click the link in our bio.

#COPD #lungs #disease #medical #research #emphysema #science #inflammation
Wishing a joyous Diwali to all those celebrating t Wishing a joyous Diwali to all those celebrating the 'festival of lights’ that marks the triumph of good over darkness. 

In acknowledging this special time, we share an illuminating image of our own - a lymph node from Dr Kieran English showcasing T cells – vital guardians protecting us from viral threats like influenza, COVID-19 and hepatitis. 

The image shows two types of T cells, cytotoxic T cells (green) which actively eliminate infected cells, alongside helper T cells (red) which help coordinate immune responses. 

Happy #Diwali!
Thank you to everyone who joined us for the Centen Thank you to everyone who joined us for the Centenary Symposium as we celebrated our achievements over the past year. We're grateful for your support and enthusiasm in our pursuit to accelerate and translate solutions to our most complex health challenges. A special thanks to our MC Dr Norman Swan who helped make the event unforgettable.  #Centenary2023 #drnormanswan #CentenaryInstitute #medicalresearch
In exciting news, Centenary Institute researchers In exciting news, Centenary Institute researchers have been awarded an Australian Research Council (ARC) Discovery Project grant worth $709,714 to advance understanding of the intricate mechanisms underlying cellular ageing.

Professor Jennifer Gamble and Dr Yanfei Qi will lead the study, investigating the ageing processes of blood vessel cells. 

They will focus on the lipid (fat) composition of the cell membrane as a potential crucial determinant in how and when cells begin to show the adverse effects of age.

Outcomes from the study, say the researchers, could include the identification of new indicators for unhealthy or premature cell ageing which contribute to age-related disease such as heart disease and dementia.

“This knowledge will provide us with a foundation to explore strategies aimed at decelerating the ageing process of these cells, ultimately with a view to fighting disease and enhancing health outcomes," said Dr Qi.

For more, click the link in our bio.

#medical #research #ageing #disease #science #heartdisease #dementia #lipids #endothelial #cells
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