Laboratories
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Bagnall
Our ability to read DNA sequence has far exceeded our ability to identify genetic variants which cause inherited diseases. To address this shortcoming, the Bioinformatics and Molecular Genetics Group develop…
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Bailey
Gene regulation is frequently dysregulated in cancer. During cancer initiation, transcription factors can exhibit somatic mutations including point mutations in regulatory domains or undergo copy number variations due to genetic…
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Bertolino and Bowen
Research within the Liver Immunology Program aims to advance our understanding of the mechanisms by which the liver induces immunological tolerance. In addition, we seek to characterise the key determinants…
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Britton
Worldwide, Tuberculosis (TB) is the 13th leading cause of death and the second leading infectious killer after COVID-19.
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Gamble
The Vascular Biology program seeks to understand the ageing process on the function of blood vessels and the impact on the development of disease. Ultimately the work may help us…
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Gorrell
The ongoing increase in all forms of liver disease is a large burden for our healthcare system. Especially the 350% increase in liver cancer in the last 30 years. Much…
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Hesselson
In the Directed Evolution laboratory, we harness the power of Darwinian selection to evolve proteins with new therapeutic activities. Starting with unique proteins from all domains of life we aim…
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Hogg
After centuries of cancer devastating almost half the population, the last decades of cancer research have brought unprecedented insights into the causation and treatment of this disease.
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Izzo
The Izzo Laboratory investigates the immune response induced to pulmonary Mycobacterium tuberculosis infection and to vaccination with new tuberculosis vaccines. The overall goal is to determine mechanisms of immunity that…
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Lyons
Cancer progression refers to the process by which cancer cells grow, spread, and develop into advanced stages. It involves the cancer cells continually changing and accumulating genetic alterations, leading to… -
McCaughan
Our work is devoted to understanding pathways at the cellular and molecular levels that drive liver injury and cancer. These pathways may then be identified as targets to modulate these…
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Philp
Research in the Philp Laboratory aims to understand the factors that cause age-associated muscle weakness to develop therapeutics to prevent sarcopenia. A fundamental cellular process thought to be involved in…
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Seth
The Genetics of Liver Disease research program includes studies on genetics of alcoholic cirrhosis and molecular mechanisms underlying liver disease. By identifying biomarkers for alcohol use and liver injury, we… -
Tiffen
The Epigenetics of Melanoma Program seeks to understand how deregulation of epigenetic modifiers can potentially govern all hallmarks of cancer. Using cutting edge techniques such as CRISPR, high throughput drug… -
Yeo
The Yeo Laboratory conducts groundbreaking translational research to develop new treatments for patients with solid tumors. We focus on understanding cancer at the molecular level to enable non-invasive monitoring, identify…
