We are driven to understand how inflammation, including immunity, drives disease processes. It is the most important fundamental mechanism by which the body’s immune system reacts to injury, for example infection or trauma. However, it also underlies a number of prevalent acute and chronic conditions, such as allergies and autoimmune diseases, and drives the initiation and progression of cancer and cardiovascular disease.
We have placed inflammation at the fulcrum of our chief clinical goals of understanding and healing inflammatory conditions (autoimmunity, allergy), cancer and cardiovascular diseases. By studying the chief cellular components of inflammation, the blood white cells and the lining of blood vessels and how they react to injury we have defined new mechanisms and devised new drug candidates.
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