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    Centenary Institute > People > Professor Mark Gorrell

Professor Mark Gorrell

Faculty

Phone number Phone Number +61 2 9565 6152

Email Email m.gorrell@centenary.org.au

Professor Mark Gorrell heads the Liver Enzymes in Metabolism and Inflammation Program. He trained in cell biology, virology, immunology and protein biochemistry at the Australian National University and University of Melbourne in Australia, and at Johns Hopkins University in the USA.

His research is focussed upon liver scarring and cancer prevention and treatment, chronic liver disease pathogenesis, diabetes, protein and enzyme biochemistry and cell biology related to the proteases DPP4, DPP9 and fibroblast activation protein (FAP).

He has authored over 160 publications attracting H index 49, i10 index 100 and > 8,000 citations. His research was important in the development of DPP4-targeted therapies for type 2 diabetes, which are now used to treat millions of patients. His research experience also includes small RNA viruses, transcriptomics, proteomics and cell biology.

Professor Gorrell has supervised more than 18 PhD and M Phil students, was the 2018 Supervisor of the Year of Sydney Research and received the 2019 SUPRA Award for a postgraduate coordinator. He is active in the International Proteolysis Society, the Gastroenterological Society of Australia, NHMRC grant reviews, and is an editorial board member for Cancers and for Scientific Reports.

 

Research

  • Gorrell

    The ongoing increase in all forms of liver disease is a large burden for our healthcare system. Especially the 350% increase in liver cancer in the last 30 years. Much of this increase is attributed to metabolic disease, often in conjunction with diabetes. Our focus in liver disease research is understanding the roles of a key enzyme family in progressive liver damage and cancer.
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Themes

  • Cancer Innovations

    Cancer Innovations
  • Inflammation

    Inflammation

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  • Liver disease
  • Diabetes

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  • Chronic diseases ,

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Research

  • Gorrell

    The ongoing increase in all forms of liver disease is a large burden for our healthcare system. Especially the 350% increase in liver cancer in the last 30 years. Much of this increase is attributed to metabolic disease, often in conjunction with diabetes. Our focus in liver disease research is understanding the roles of a key enzyme family in progressive liver damage and cancer.
    Read more

News

  • DPP9 deficit linked to immune disorders in children

    Researchers, including from the Centenary Institute, have reported that ultra-low levels of the dipeptidyl peptidase 9 (DPP9) enzyme could be contributing to immune disorders in children.
    Date 04 Oct 2022
  • DPP9 enzyme role in cancer revealed

    A new study from German and Centenary Institute researchers has provided new understanding of an enzyme called dipeptidyl peptidase 9 (DPP9) and its role in cancer development.
    Date 04 Aug 2022
  • Meet Professor Mark Gorrell

    Hi, I’m Mark and I’m Head of the Liver Enzymes in Metabolism and Inflammation Program at Centenary.
    Date 04 Mar 2019
    Prof Mark Gorrell Prof Mark Gorrell
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