Expertises: Epigenetics

About the talk: Cellular senescence is a permanent form of cell cycle arrest triggered by accumulated stochastic damage to cells. Dysregulation of cellular metabolism and epigenetic modifications are two important hallmarkers of cellular senescence. We have previously identified pyruvate kinase (Pyk1) as a moonlighting protein that coordinates cell metabolism and histone modifications by forming a ...

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New research from the Centenary Institute has provided novel insights into the role of these spacer DNA or introns in the development and function of monocytes and macrophages, essential components of the innate immune system.

World-class research into melanoma, the deadliest form of skin cancer, has been boosted with Dr Jessamy Tiffen, Head of the Centenary Institute's Melanoma Epigenetics Laboratory, receiving a $447,000 project grant from Cancer Council NSW.

Centenary Institute researchers have secured more than $2m in collective funding from the Federal Government in the latest round of National Health and Medical Research Council (NHMRC) Ideas Grants.

Two Centenary Institute scientists have been awarded grants totalling $4.3 million from the Cancer Institute NSW to undertake critical cancer related medical research.

Dr Jessamy Tiffen has been promoted to the Scientific Faculty at the Centenary Institute where she will be a part of the senior science leadership team.

Research conducted at the Centenary Institute has unveiled crucial insights into the underlying molecular mechanisms of breast cancer. The findings could lead to a more effective treatment for the disease, which claims the lives of over 3,000 Australian women and men annually.