Skip to content
Home page - Centenary Institute Centenary Institute

Primary menu

  • Research
        • Research

          The latest medical research into our most complex health challenges across cancer, cardiovascular disease and inflammation

          Learn more

        • Cancer
        • Inflammation
        • Cardiovascular
        • Programs
        • Laboratories
        • Diseases
        • Expertises
        • Services and instrumentation
  • Support us
        • Support us

          By supporting the Centenary Institute you can help improve human health through excellence in medical research

          Learn more

        • Workplace giving
        • Host or join a fundraiser
        • Gift in your Will
        • Donate in Memory
  • Impact
        • Impact

          Our research develops new diagnostics, treatments and cures for some of the most deadly and debilitating diseases affecting society today

          Learn more

        • Breakthroughs
        • Community and research
        • Real stories
  • Health hub
        • Health hub

          A range of practical information to assist in the possible preventions to disease through evidence-based research on how the body works.

          Learn more

        • Inflammation
        • The Good Gut Anti-Inflammatory Diet
        • Ageing
        • Exercise Snack Program
  • News & events
        • News & Events

          Explore the latest research breakthroughs and ways you can take part in our series of digital and in-person events

        • News
        • Events
        • Media Hub
  • About us
        • About us

          We are world-leading independent medical research institute that drives collaboration to accelerate and translate solutions to our most complex health challenges

          Learn more

        • Governance
        • Corporate information
        • Annual reports
        • Our researchers
        • Careers and studies
        • Contact
  • Donate
    Centenary Institute > News > TB shown to remodel lymph nodes affecting immune response

TB shown to remodel lymph nodes affecting immune response

Date time 8 November, 2022
News Type News type Research News
Centenary Institute and University of Sydney PhD student, Lina Daniel, is lead author on a newly published paper that has found that Mycobacterium tuberculosis remodels the architecture of the lymph nodes – limiting the immune system’s ability to overcome tuberculosis (TB) infection.

The bacteria responsible for TB, Mycobacterium tuberculosis kills approximately 1.6 million people each year globally.

In their study, on mice, Lina Daniel and collaborating authors showed for the first time  that tuberculosis infection in the lungs leads to disruption of the normal organised structure and function in the lymph nodes draining the lung.

The restructuring of the lymph nodes due to Mycobacterium tuberculosis was driven by an accumulation of B cells. Ultimately, this restructuring led to reduced activation of T cells that protect against TB infection.

“This restructuring of the lymph node is another way that TB prevents the immune system from eradicating the infection,” said Lina Daniel.

The paper was published in the high-impact Journal of Clinical Investigation.

Publication: Stromal structure remodeling by B lymphocytes limits T cell activation in lymph nodes of Mycobacterium tuberculosis–infected mice.

Themes

  • Inflammation

    Inflammation

Programs

  • Tuberculosis Research Program

Media enquires

For all media and interview enquiries, please contact Tony Crawshaw, Media and Communications Manager

Phone number Phone Number 0402 770 403

Email Email t.crawshaw@centenary.org.au

Recent Stories

  • Metastatic cancer research boosted

    Dr Dannel Yeo from the Centenary Institute and Clinical Associate Professor Kate Mahon from Chris O’Brien Lifehouse, have been awarded an inaugural Sydney Cancer Partners Translational Fellowship.
    News Type: Research News
    Date 03 Mar 2023
  • The Year That Made Me: Professor John Rasko

    Professor John Rasko AO, Head of the Gene and Stem Cell Therapy Program at the Centenary Institute has featured on the popular Radio National show Sunday Extra in the segment called ‘The Year That Made Me’.
    News Type: Media coverage
    Date 21 Feb 2023
  • Top abstract prize for gene therapy research

    Professor John Rasko AO and team have received the top scoring abstract award at the 16th Annual Congress of the European Association for Haemophilia and Allied Disorders in Manchester.
    News Type: Research News
    Date 15 Feb 2023
  • Event celebrates ‘The Good Gut Anti-Inflammatory Diet’

    The Centenary Institute has celebrated the publication of a new book, 'The Good Gut Anti-Inflammatory Diet’ at a special event, held at the Dymocks Bookstore, Sydney.
    News Type: Community
    Date 13 Feb 2023

Subscribe to receive news on
research updates and free events

Newsletter

The Centenary Institute is a world-leading independent Medical Research Institute.

We acknowledge the Gadigal of the Eora Nation, the traditional custodians of the Country on which the Centenary Institute stands.

About

  • About
  • Governance
  • Corporate information

Research

  • Programs
  • Our researchers
  • News
  • Media hub

Careers & studies

  • Career opportunities
  • Life at Centenary

Links

  • Contact
  • Privacy statement

Contact us

Building 93, Royal Prince Alfred Hospital
Missenden Rd
Camperdown NSW 2050 Australia
Telephone +61 2 9565 6100
Fax +61 2 9565 6101

Centenary Institute ABN 22 654 201 090 (DGR 1) • Centenary Institute Medical Research Foundation ABN 85 778 244 012 (DGR 2)
© 2017 Centenary Institute of Cancer Medicine and Cell Biology.

  • Linkedin
  • Facebook
  • Twitter
  • Youtube
  • Instagram