Dr Chuck (Charles) Bailey, is the head of the Cancer and Gene Regulation Laboratory at the Centenary Institute. He trained as a molecular and cellular biologist (PhD, CRC for Biopharmaceutical Research, UNSW) and has 20 years’ experience in studying molecular mechanisms of genetic disease and cancer. In 2001, he joined the Gene and Stem Cell Therapy Program headed by Professor John Rasko at the Centenary Institute studying the molecular genetics of human amino acid transporter disorders. His work lead to the discovery of the genetic causes of 3 of the 5 principal inherited amino acid transport disorders in humans, published in Nature Genetics and The Journal of Clinical Investigation (x2).
He was appointed as a Senior Research Officer in 2007 and where he began studying the role of transcription factors in cancer causation. By understanding fundamental gene regulatory mechanisms in normal biology, he is applying this knowledge to elucidating aberrant transcription factor function in cancer. With a particular focus on the chromatin organising protein CTCF, and its paralogue BORIS, he has been examining gene regulatory circuitry and protein interaction networks that are essential in cancer.