Skip to content
Home page - Centenary Institute Centenary Institute

Primary menu

  • Research
        • Research

          The latest medical research into our most complex health challenges across cancer, cardiovascular disease and inflammation

          Learn more

        • Cancer
        • Inflammation
        • Cardiovascular
        • Programs
        • Laboratories
        • Diseases
        • Expertises
        • Services and instrumentation
  • Support us
        • Support us

          By supporting the Centenary Institute you can help improve human health through excellence in medical research

          Learn more

        • Workplace giving
        • Host or join a fundraiser
        • Gift in your Will
        • Donate in Memory
  • Impact
        • Impact

          Our research develops new diagnostics, treatments and cures for some of the most deadly and debilitating diseases affecting society today

          Learn more

        • Breakthroughs
        • Community and research
        • Real stories
  • Health hub
        • Health hub

          A range of practical information to assist in the possible preventions to disease through evidence-based research on how the body works.

          Learn more

        • Inflammation
        • The Good Gut Anti-Inflammatory Diet
        • Ageing
        • Exercise Snack Program
  • News & events
        • News & Events

          Explore the latest research breakthroughs and ways you can take part in our series of digital and in-person events

        • News
        • Events
        • Media Hub
  • About us
        • About us

          We are world-leading independent medical research institute that drives collaboration to accelerate and translate solutions to our most complex health challenges

          Learn more

        • Governance
        • Corporate information
        • Annual reports
        • Our researchers
        • Careers and studies
        • Contact
  • Donate
    Centenary Institute > People > Professor Mark Gorrell

Professor Mark Gorrell

Head of Liver Enzymes in Metabolism and Inflammation Program

Phone number Phone Number +61 2 9565 6152

Email Email m.gorrell@centenary.org.au

Professor Mark Gorrell heads the Liver Enzymes in Metabolism and Inflammation Program. He trained in cell biology, virology, immunology and protein biochemistry at the Australian National University and University of Melbourne in Australia, and at Johns Hopkins University in the USA.

His research is focussed upon liver scarring and cancer prevention and treatment, chronic liver disease pathogenesis, diabetes, protein and enzyme biochemistry and cell biology related to the proteases DPP4, DPP9 and fibroblast activation protein (FAP).

He has authored over 160 publications attracting H index 49, i10 index 100 and > 8,000 citations. His research was important in the development of DPP4-targeted therapies for type 2 diabetes, which are now used to treat millions of patients. His research experience also includes small RNA viruses, transcriptomics, proteomics and cell biology.

Professor Gorrell has supervised more than 18 PhD and M Phil students, was the 2018 Supervisor of the Year of Sydney Research and received the 2019 SUPRA Award for a postgraduate coordinator. He is active in the International Proteolysis Society, the Gastroenterological Society of Australia, NHMRC grant reviews, and is an editorial board member for Cancers and for Scientific Reports.

 

Research

  • Liver Enzymes in Metabolism and Inflammation Program

    The ongoing increase in all forms of liver disease is a large burden for our healthcare system. Especially the 350% increase in liver cancer in the last 30 years. Much of this increase is attributed to metabolic disease, often in conjunction with diabetes. Our focus in liver disease research is understanding the roles of a key enzyme family in progressive liver damage and cancer.
    Read more

Themes

  • Cancer

    Cancer
  • Inflammation

    Inflammation

Research Fields

  • Liver disease
  • Diabetes

Topics

  • Chronic diseases ,

Publications

Recent publications

Search amongst our repository

all publications

For access to all Publications via Pub Med.

Research

  • Liver Enzymes in Metabolism and Inflammation Program

    The ongoing increase in all forms of liver disease is a large burden for our healthcare system. Especially the 350% increase in liver cancer in the last 30 years. Much of this increase is attributed to metabolic disease, often in conjunction with diabetes. Our focus in liver disease research is understanding the roles of a key enzyme family in progressive liver damage and cancer.
    Read more

News

  • DPP9 deficit linked to immune disorders in children

    Researchers, including from the Centenary Institute, have reported that ultra-low levels of the dipeptidyl peptidase 9 (DPP9) enzyme could be contributing to immune disorders in children.
    Date 04 Oct 2022
  • DPP9 enzyme role in cancer revealed

    A new study from German and Centenary Institute researchers has provided new understanding of an enzyme called dipeptidyl peptidase 9 (DPP9) and its role in cancer development.
    Date 04 Aug 2022
  • Meet Professor Mark Gorrell

    Hi, I’m Mark and I’m Head of the Liver Enzymes in Metabolism and Inflammation Program at Centenary.
    Date 04 Mar 2019
    Prof Mark Gorrell Prof Mark Gorrell
View all

Twitter

Tweets by CentenaryInst Follow us (links open in a new window)

Subscribe to receive news on
research updates and free events

Newsletter

The Centenary Institute is a world-leading independent Medical Research Institute.

We acknowledge the Gadigal of the Eora Nation, the traditional custodians of the Country on which the Centenary Institute stands.

About

  • About
  • Governance
  • Corporate information

Research

  • Programs
  • Our researchers
  • News
  • Media hub

Careers & studies

  • Career opportunities
  • Life at Centenary

Links

  • Contact
  • Privacy statement

Contact us

Building 93, Royal Prince Alfred Hospital
Missenden Rd
Camperdown NSW 2050 Australia
Telephone +61 2 9565 6100
Fax +61 2 9565 6101

Centenary Institute ABN 22 654 201 090 (DGR 1) • Centenary Institute Medical Research Foundation ABN 85 778 244 012 (DGR 2)
© 2017 Centenary Institute of Cancer Medicine and Cell Biology.

  • Linkedin
  • Facebook
  • Twitter
  • Youtube
  • Instagram