Home > Research > Inflammation > CeNTM: Centenary Non-Tuberculous Mycobacteria research centre

CeNTM: Centenary Non-Tuberculous Mycobacteria research centre

About the CeNTM

CeNTM encompasses Centenary’s biomedical research on Non-Tuberculous Mycobacteria (NTM) providing a network for capacity and expertise sharing. We have a specific focus on Mycobacterium abscessus, as this is an emerging NTM species of significance due to high level antibiotic resistance and low cure rates in at risk populations such as those with underlying genetic and structural abnormalities.

Our research teams have expertise spanning bacteriology, in vitro human cellular infection models, and mouse and zebrafish infection models which we use to investigate the pathogenesis of NTM infections and discover new treatments for infection.

Our laboratory space is fitted for bacterial culture and in vitro infection assays to test novel antimicrobial compounds and host-directed therapies against NTM species. Furthermore, we are well equipped to explore bacterial virulence factors and cellular host-pathogen interactions underpinning NTM disease pathogenesis. We have dedicated infection and imaging suites for performing and analysing medium throughput zebrafish embryo infections and have pioneered the use of adult zebrafish as a model of persistent M. abscessus infection.

As Australia’s largest concentration of NTM researchers, we can provide antimicrobial testing capacity across our range of in vitro and in vivo platforms for experimental molecules as a collaboration.

Our Investigators

Led by

Dr Matt Johansen
Dr Stefan Oehlers

Chief Investigators

Professor Jamie Triccas
Professor Phil Hansbro
Professor Warwick Britton

Some of our projects

  • Anti-microbial testing – Dr Johansen
  • Host immunopathogenesis – Dr Oehlers
  • Vaccine development – Professor Triccas
  • Clinical isolate phenotyping and investigation of extreme infection phenotypes
  • Host genetic susceptibility to NTM infection

Recruitment

We are interested in hearing from students (through USyd or UTS) and postdocs interested in joining one of our teams and working with non-tuberculous mycobacteria. Alongside the Centenary-UTS Centre for Inflammation and Centenary’s Tuberculosis Research Program we offer an excellent training environment amongst a vibrant cohort of respiratory infection and immunity researchers. Please contact us on email.