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    Centenary Institute > People > Professor Axel Ullrich
Prof Axel Ullrich
Prof Axel Ullrich

Professor Axel Ullrich

Max Planck Institute for Biochemistry, Germany

Professor Ullrich is a pioneer in cancer research and is responsible for the discovery of the HER2/neu oncogene, the basis for Herceptin (Trastuzumab), the breakthrough therapeutic for breast cancer.

Trastuzumab has not only delivered a major clinical benefit to women (a 50% decrease in tumour recurrence) not seen since the introduction of tamoxifen a decade ago, but also initiated the era of personalised medicine.

His work in the field of signal transduction has elucidated major fundamental molecular mechanisms, such as protein phosphorylation, that govern the physiology of normal cells and allowed insights into pathophysiological mechanisms of major human diseases.

More recently, Prof Ullrich has been responsible for developing the first multi-targeted kinase inhibitor, SU11248/SUTENT, for the treatment of cancer.

SUTENT has recently passed Phase III studies and is under consideration for approval for treatment of malignant gastrointestinal stromal tumours and metastatic renal cell carcinoma.

News

  • New platform to evolve proteins for better therapies

    Researchers from the Centenary Institute, in collaboration with the University of Sydney, have developed a powerful new tool to evolve proteins directly within mammalian cells, offering a more effective way to design medical treatments tailored to the human body.
    Date 08 May 2025
  • Turning off protein may help prevent liver cancer

    New research from the Centenary Institute has found that switching off a specific protein in liver cells may help prevent the early development of liver cancer.
    Date 16 Apr 2025
  • Event shines spotlight on genetic heart disease in young people

    The Centenary Institute has hosted a community event, titled ‘A Needle in a Haystack: Unlocking the Secrets of Genetic Heart Conditions’. The event aimed to advance understanding of inherited heart disease and sudden cardiac death in young people.
    Date 10 Apr 2025
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