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    Centenary Institute > People > Professor Jennifer Gamble

Professor Jennifer Gamble

Head of Vascular Biology Program

Wenkart Chair of Endothelium Medicine, Central Clinical School

Programs

  • Vascular Biology Program

Laboratories

  • Lipid Cell Biology

Phone number Phone Number +61 2 9565 6225

Email Email j.gamble@centenary.org.au

Professor Jennifer Gamble is an internationally recognised research leader in the field of endothelial cell function and holds the Inaugural Wenkart Chair of the Endothelium.

Her interests lie in understanding the function of blood vessels, particularly the endothelial cells that form the barrier between the blood and the tissues. Her initial work on the action of TNF on the endothelium to support neutrophil adhesion redefined and forms the basis for our understanding of the central role of the endothelium in inflammation.

She has been instrumental in defining the concept of positive and negative regulators of the endothelium, their role in inflammation and barrier function and the signaling pathways involved. She has identified and characterised the role of new genes which regulate endothelial cell function, with her recent work focusing on understanding endothelial cell ageing or cellular senescence. She has recently discovered the function of the gene, called SENEX or ARHGAP18, which provides a unique gatekeeper function in limiting the stress induced premature senescence and inflammation pathways in endothelial cells.

Her laboratory is expanding into studies on pericytes, smooth muscle cells and perivascular macrophages, all cells which interact with endothelial cells and which together control blood vessel function. The laboratory utilises state of the art single cell analysis, high resolution imaging, metabolic studies and animal models in their investigations.

Diseases being investigated are Alzheimer’s disease and heart disease.

Themes

  • Cardiovascular

    Cardiovascular

Topics

  • Ageing ,
  • Chronic diseases ,

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    Researchers at the Centenary Institute and the University of Technology Sydney have identified a new drug target for the treatment and prevention of chronic obstructive pulmonary disease (COPD), an inflammatory lung disease that causes airway blockage and that makes it difficult to breathe.
    Date 04 Jul 2022
  • Inflammation presentation awarded

    Dr Joyce Chiu from the ACRF Centenary Cancer Research Centre has won an Oral Communication Award for her talk given at the 15th World Congress on Inflammation, held in Rome, June 2022.
    Date 01 Jul 2022
  • Meet Dr Annalicia Vaughan

    A medical researcher at the Centenary UTS Centre for Inflammation, Dr Annalicia Vaughan specialises in the gut-lung axis and its role in lung and respiratory diseases.
    Date 28 Jun 2022
    Dr Vaughan Dr Vaughan
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© 2017 Centenary Institute of Cancer Medicine and Cell Biology.

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