Themes: Cardiovascular Research

Abstract: Lipids comprise thousands of individual species, spanning many classes and subclasses and are integral to cellular signalling, metabolism and function. Genome-wide association studies (GWAS) of lipid species can provide novel insights into human physiology, inborn errors of metabolism andmechanisms for complex traits and diseases. We integrated lipidomics and genomics to unravel the genetic architecture ...

We have partnered with the Royal Botanic Garden Sydney and Australian Museum in celebration of science and National Science Week

About the talk: Our blood vessel system is an extremely complex network consisting of distinct vessel types including arteries, capillaries and veins. These different vessel beds also experience local environmental cues that drive tissue specific vascular network through organotypic differentiation. Transmembrane integrin heterodimers formed by a-and β-subunits are the major adhesion receptors that reside at the ...

Ageing represents one of the greatest medical, social and economic challenges – in Australia and globally.

About the talk: In this presentation, Connie will go through some of our recent published and unpublished work on the effect of stroke on the lung neutrophil function and gut barrier integrity. Connie and her team believe revealing the underlying mechanisms behind stroke-induced impairment of these vulnerable mucosal sites will lead to the discovery of ...

Ever wondered what it’s like to be a scientist?

About the talk: Exercise training has a powerful influence on cardiac structure and function and yet even within teams of elite athletes there is marked individual variation. Could it be that genetic influences are accentuated by the haemodynamic stressors of exercise and that athletes could provide the perfect platform for understanding inherited influences on cardiac function?Andre ...

About the talk: Biomaterials play a central role in modern regenerative medicine and tissue engineering strategies, where they serve as tuneable environments that direct cellular behaviour and function. However, one of the biggest obstacles in translating advances in biomaterials research to clinical applications is lack of sufficient vascular tissue regeneration. We develop silk fibroin-based biomaterials ...

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About the talk: Sudden cardiac arrest in the young (1-50) is a common condition, affecting 3000 Australians nationally with 90% mortality. In Victoria, the End Unexplained Cardiac Death (EndUCD) registry commenced in 2019, with prospective collection of all out-of-hospital cardiac arrests attended by Ambulance Victoria. These cardiac arrests have comprehensive adjudication against hospital and forensic data, ...

We invite you to join us in person at Rydges Camperdown or online for our free event ‘A needle in a haystack: unlocking the secrets of genetic heart conditions’. You will hear from Peter Wilson, Head of Philanthropy at the Centenary Institute who will provide an introduction and update on the Institute. This will be followed ...

To honour Professor Mathew Vadas AO and his sixteen years as Executive Director of the Centenary Institute we will host a Symposium of Medical Research Excellence.

Centenary’s Inclusion Gender Equity Program (IGEP) brings an entertaining and exciting half-day event

The Centenary Institute will host an Exhibition at Parliament House Sydney showcasing images taken by our scientists as part of their research endeavours that have both scientific significance and are visual masterpieces!  The Scientific Image Prize is an annual internal competition designed to recognise the incredible research of Centenary’s scientists, as well as their artistic ...

Centenary Institute researchers have been awarded an Australian Research Council (ARC) Discovery Project grant worth $709,714 to advance understanding of the intricate mechanisms underlying cellular ageing.

Centenary Institute researchers in the Agnes Ginges Centre for Molecular Cardiology have secured $2.7 million in funding for nationally significant research into cardiovascular disease and sudden cardiac death.

Professor Christopher Semsarian AM, Head of the Agnes Ginges Centre for Molecular Cardiology at the Centenary Institute and a cardiologist at Royal Prince Alfred Hospital, has provided expert commentary on the ABC, on the role of genetics in heart disease and the growing significance of DNA analysis in court proceedings. According to Professor Semsarian, advanced ...

The Centenary Institute’s Agnes Ginges Centre for Molecular Cardiology has celebrated twenty years of world-leading research into the diagnosis, treatment and prevention of genetic heart diseases and sudden cardiac death in the community.

Originally from Canada, Dr Dan Hesselson, Head of the Centenary Institute’s Directed Evolution Laboratory, has a true passion for ice hockey, a sport he played regularly as a child and one which he still plays recreationally now.

The Centenary Institute has engaged with kids and the wider community as the Research Partner of Sydney Science Trail held at the Botanic Gardens and Australian Museum in celebration of National Science Week.

Professor Chis Semsarian AM, Head of the Agnes Ginges Centre for Molecular Cardiology at the Centenary Institute and Cardiologist at the Royal Prince Alfred Hospital, has given a headline talk on the genetic basis of cardiovascular disease as a part of Sydney Local Health District’s 'Innovation Week' event.

New research from the Centenary Institute has identified specific blood fats that can predict how effectively individuals with pre-diabetes will improve their blood sugar levels through diet and weight loss. These findings could pave the way for more personalised approaches to preventing and managing type 2 diabetes.

The lymph node is bean shaped mass and is one of approximately 450 in the body.

Professor Christopher Semsarian AM, Head of the Centenary Institute’s Agnes Ginges Centre for Molecular Cardiology has been recognised by the University of Sydney’s Cardiovascular Initiative (CVI) and been presented with an award for ‘Most Collaborative Cardiovascular Researcher’.

A new review has shown how medical professionals in cardiology can help reduce healthcare’s carbon footprint, by making small, low-cost changes in how they work. The review, published today in the prestigious Open Heart journal, explores the environmental impact of cardiovascular healthcare.

Genetic testing can diagnose cardiomyopathy – a disease of the heart muscle – in children and help detect who will have heart failure and require a transplant, a new study has found.

You may have wondered what makes stem cells so important and why they are needed for medical research.

The Centenary Institute has given members of the public, school students and stakeholders the opportunity to find out what it’s like to be a scientist – and to better understand what it takes to be at the cutting-edge of medical discovery – with its unique ‘speed dating’ event, held as part of the Spark Festival.

Dr Jessica Orchard, Research Fellow in the Agnes Ginges Centre for Molecular Cardiology and Heart Foundation Postdoctoral Fellow has been promoted to the Centenary Institute’s Scientific Associate Faculty based on research excellence, productivity and emerging leadership qualities.

Dr Jessica Orchard, Associate Faculty member at the Centenary Institute, together with Professor Ben Freedman from the Heart Research Institute, have written an article for The Conversation on wearable technologies and heart health.

A breakthrough discovery in understanding how white blood cells move in the body could pave the way for new treatments for chronic inflammation-related diseases including cardiovascular diseases, according to a recent study from the Centenary Institute.

This International Day of Women and Girls in Science, we profile Emma Singer, a PhD student and Research Assistant in the Centenary Institute’s Bioinformatics and Molecular Genetics Laboratory.

World-leading research into heart muscle disease has been boosted with the Centenary Institute’s Associate Professor Mathias Francois and team awarded a National Health and Medical Research Council (NHMRC) Ideas Grant to investigate left ventricular non compaction cardiomyopathy (LVNC).

The Sydney Morning Herald has reported study findings from the Centenary Institute that found that concealed cardiomyopathy – heart muscle disease that can cause fatal heart rhythms – is an important cause of sudden cardiac death where no cause is found from autopsy.

Dr Richard Bagnall, Head of the Centenary Institute’s Bioinformatics and Molecular Genetics Laboratory, has been interviewed on Radio 2GB’s Healthy Living program.

Researchers from the Centenary Institute have found that concealed cardiomyopathy is an important cause of sudden cardiac death where no cause is found from autopsy – and that genetic testing can help identify cases of concealed cardiomyopathy which provides a cause of death and also helps guide care of surviving relatives.

Vascular endothelial cells serve as a protective barrier in blood vessel walls.

Dr Jessamy Tiffen, a senior member of the Centenary InstituteÕs Melanoma Immunology and Oncology Program has some sage advice for aspiring female scientists in advance of this year's 'International Day of Women and Girls in Science'.

Some of our leading cancer researchers, Professor Phil Hansbro, ProfessorÊPeter Hersey, Dr Mainthan Palendira and DrÊJessamy Tiffen have presented their project updates and recent findings to consumers and supporters at our recent consumer engagement session.

Professor Christopher Semsarian AM, Head of the Agnes Ginges Centre for Molecular Cardiology at the Centenary Institute and Dr Michael J. Ackerman, M.D. (Mayo Clinic) have jointly participated in a live Q&A session on the topic of COVID-19 and genetic heart disease.

Four scientists from the Centenary Institute have had their world-leading research recognised by being awarded prestigious NSW Cardiovascular Research Capacity Building Grants. The grants will help drive the scientists work focused on improving the health of patients with heart and cardiovascular conditions.

Co-operation between cardiovascular researchers from the University of Zurich with researchers from the ÔLiver Enzymes in Metabolism and Inflammation ProgramÕ at the Centenary Institute have produced a breakthrough in understanding how atherosclerotic plaques (fatty deposits in arteries) form and stabilise.

Researchers from the Centenary Institute have discovered a potential new therapy for cerebral cavernous malformations (CCMs), a devastating disease that often affects young people and can result in stroke and seizures.

CentenaryÕs Summer Research Scholarship program for 2020/21 is now open and accepting applications!

Centenary Institute researchers have discovered that genetic testing can identify Ôconcealed cardiomyopathiesÕ in nearly a quarter of sudden cardiac arrest (SCA) survivors who seem to have a normal heart.

In a momentous breakthrough, Australian scientists have found that humans, and most likely the entire animal kingdom, share important genetic mechanisms with a jelly-like sea sponge that comes from the Great Barrier Reef.

World-leading research into sudden cardiac death (SCD) in young people and multiple sclerosis has been boosted with two Centenary Institute researchers successfully securing prestigious Ideas Grants in the latest round of National Health and Medical Research Council (NHMRC) funding.

The Centenary InstituteÕs Summer Research Scholarship Program for undergraduate students has drawn to a close with 14 Êstudents undertaking a series of Ôrapid-fireÕ style presentations to staff, explaining their completed research projects and talking about their work-related experiences at Centenary over the summer months.

Early career researchers from three of SydneyÕs leading medical research institutes, the Centenary Institute, the Heart Research Institute and the Woolcock Institute have come together to deliver the ÔECR Think Tank ProgramÕ for 2021.

Dr Jessica Orchard, a Postdoctoral Fellow at the Centenary Institute and the University of Sydney has written an article for The Conversation following the dramatic collapse of DenmarkÕs Christian Eriksen when his heart stopped during a recent Euro 2021 football match.

Professor Chris Semsarian AM, Head of the Agnes Ginges Centre for Molecular Cardiology at the Centenary Institute and spokesperson for the Cardiac Society of Australia and New Zealand, has been interviewed by the Sydney Morning Herald (SMH) on his response to recent studies linking PfizerÕs COVID-19 vaccine with myocarditis, particularly in young men.

Dr Jessica Orchard, a Centenary Institute researcher at the Agnes Ginges Centre for Molecular Cardiology and a Heart Foundation Postdoctoral Fellow, has been interviewed for the latest Medical Journal of Australia (MJA) podcast.

World-leading research into cardiovascular disease has been boosted with three researchers from the Centenary Institute securing Cardiovascular Research Capacity Program grants from the NSW Government.

Research led by the Centenary Institute and the Harvard Medical School, Boston, shows that a compound present in current beta blocker treatments could be repurposed to increase efficiency and safety of infantile hemangioma therapies.

For the past four years, the University of Canberra Stars Football Club has raised vital funds for the Centenary Institute in honour of Aaiden Bellingham, who was tragically lost in 2017. Now, they’re back for 2022 with the launch of the annual Bellingham Cup. The annual pre-season tournament focuses on bringing the club together to ...

Australian cricketer Shane Warne tragically passed away from a suspected heart attack at the age of 52. In a new episode of the ‘Racing Heart’ podcast, produced by the National Centre for Sport Cardiology, Dr Jessica Orchard (Heart Foundation Postdoctoral Fellow at the Centenary Institute) and Associate Professor Andre La Gerche (Head of Sports Cardiology ...

Professor Chris Semsarian AM, Head of the Centenary Institute’s Agnes Ginges Centre for Molecular Cardiology, has featured in an article in Research Australia’s Inspire Magazine outlining the importance of philanthropy to medical research. The article highlights how the philanthropic support of Mrs Agnes Ginges and her husband, the late Mr Berel Ginges (facilitated by eminent ...

Associate Professor Mathias Francois established the Centenary Institute’s ‘David Richmond Laboratory for Cardiovascular Development: Gene Regulation and Editing’ back in June 2019. It’s the architecture and complexity of the vascular system in humans that he finds particularly fascinating, especially their mode of assembly during embryonic development.

Hi I’m Richard and I work in the Molecular Cardiology Program at Centenary.

Hi, I'm Nick and I'm the Chief Operating Officer at Centenary.

Hi, I'm Katrina and I'm in charge of Translation and Commercialisation at Centenary.

Hi, I’m Kristina and my job is to ensure that our high-tech state-of-the-art microscopes at Centenary are operating well and that all staff, including students, know how to use them correctly for their research.

Centenary Institute researcher and PhD candidate, Dr Julia Isbister, has been awarded the 2022 Ralph Reader Prize for Clinical Science by the Cardiac Society of Australia and New Zealand (CSANZ).