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    Centenary Institute > Services and instrumentation > Genome Imaging Centre

Genome Imaging Centre

The Genome Imaging Centre is advancing, and making widely available, single molecule imaging technology to push the very boundary of genome biology investigation. Valuable new insights into the body, disease, drug discovery and potential cures are being enabled.

The relationship between the organisation of the genome, over both space and time, and its function, is an outstanding question in biology. This key biological process faces dysregulation and underpins many diseases such as cancer and cardio-vascular disorders.

The establishment of the Centenary Institute’s Genome Imaging Centre and its advanced new super resolution microscopy allows for high-contrast single molecule imaging in living cells in order to decipher the molecular principle of gene regulation dynamics.

Offering a comprehensive technology training platform, the Centre is able to undertake quantitative molecular imaging of the dynamic genome with a freely accessible repository and analysis toolkit.

This rare specialised training and multi-modal imaging capability enhances opportunities to extend and enrich scientific knowledge across Centenary’s existing medical research programs, with new external users also supported.

The Genome Imaging Centre is the first of its kind in Australia, providing new capability in basic science to analyse and better understand molecular mechanisms in gene regulation. Applied science–including innovative drug discovery, industry collaboration and potential future biotechnology spin-outs is also a focus.

Technology training by the Centre provides non-expert research groups with access to cutting edge new approaches in quantitative molecular imaging applied to genome biology.

The Centre is able to assist in experimental design and training applied to single molecule localisation microscopy such as TIRFF, HILO, dSTORM and STEAD. Access to a unique computational pipeline to process, analyse and visualise large datasets is also provided. A transcription factor dashboard developed in collaboration with the Sydney Informatics Hub – The University of Sydney serves as a repository for single molecule data sets that could be used for data such as chromatin mobility and epigenetics maps.

The Centre supports the development of new methods applied to genome imaging such as PAINT, smFISH, MERFISH or LIVE MIEL based on unique access to this technology via a national and international network of collaborators across the globe.

 

Associate Professor Mathias Francois

Head, David Richmond Laboratory for Cardiovascular Development: Gene Regulation and Editing Program

Associate Professor Till Boecking, UNSW

Professor Susan Clark, Garvan Institute

Dr Matt Graus, Centenary Institute

Dr Elizabeth Hinde, University of Melbourne

 

Dr Peter Su, University of Technology Sydney

Distinguished Professor Antoine van Oijen, University of Wollongong

Dr Emily Wong, Victor Chang Cardiac Research Institute

Australian

Peter MacCallum Cancer Centre, Kieran Harvey laboratory

University of Melbourne, Elizabeth Hinde laboratory

University of Sydney, Charles Perkins Centre

University of Sydney, Sydney Informatic Hub (SIH)

University of Technology Sydney, Peter Su laboratory

Victor Chang Cardiac Research Institute, Richard Harvey laboratory

International

Hiroshima University, Hiroshi Ochiai laboratory

IRCCS Opedale San Raffaele, Davide Mazza laboratory

Sanford Burnham Prebys Medical Discovery Institute, Alexey Tserkikh laboratory

University of Ulm, Christof Gebhardt laboratory

If you are interested in applying for a research training. Please contact Dr Matt Graus.

 

Services and instrumentation

  • Genome Imaging Centre

The Genome Imaging Centre is the first of its kind in Australia, providing new capability in basic science to analyse and better understand molecular mechanisms in gene regulation. Applied science–including innovative drug discovery, industry collaboration and potential future biotechnology spin-outs is also a focus.

Technology training by the Centre provides non-expert research groups with access to cutting edge new approaches in quantitative molecular imaging applied to genome biology.

The Centre is able to assist in experimental design and training applied to single molecule localisation microscopy such as TIRFF, HILO, dSTORM and STEAD. Access to a unique computational pipeline to process, analyse and visualise large datasets is also provided. A transcription factor dashboard developed in collaboration with the Sydney Informatics Hub – The University of Sydney serves as a repository for single molecule data sets that could be used for data such as chromatin mobility and epigenetics maps.

The Centre supports the development of new methods applied to genome imaging such as PAINT, smFISH, MERFISH or LIVE MIEL based on unique access to this technology via a national and international network of collaborators across the globe.

 

Associate Professor Mathias Francois

Head, David Richmond Laboratory for Cardiovascular Development: Gene Regulation and Editing Program

Associate Professor Till Boecking, UNSW

Professor Susan Clark, Garvan Institute

Dr Matt Graus, Centenary Institute

Dr Elizabeth Hinde, University of Melbourne

 

Dr Peter Su, University of Technology Sydney

Distinguished Professor Antoine van Oijen, University of Wollongong

Dr Emily Wong, Victor Chang Cardiac Research Institute

Australian

Peter MacCallum Cancer Centre, Kieran Harvey laboratory

University of Melbourne, Elizabeth Hinde laboratory

University of Sydney, Charles Perkins Centre

University of Sydney, Sydney Informatic Hub (SIH)

University of Technology Sydney, Peter Su laboratory

Victor Chang Cardiac Research Institute, Richard Harvey laboratory

International

Hiroshima University, Hiroshi Ochiai laboratory

IRCCS Opedale San Raffaele, Davide Mazza laboratory

Sanford Burnham Prebys Medical Discovery Institute, Alexey Tserkikh laboratory

University of Ulm, Christof Gebhardt laboratory

If you are interested in applying for a research training. Please contact Dr Matt Graus.

 

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