Themes: Inflammation

Ageing represents one of the greatest medical, social and economic challenges – in Australia and globally.

We have partnered with the Royal Botanic Garden Sydney and Australian Museum in celebration of science and National Science Week

Abstract: Lipids comprise thousands of individual species, spanning many classes and subclasses and are integral to cellular signalling, metabolism and function. Genome-wide association studies (GWAS) of lipid species can provide novel insights into human physiology, inborn errors of metabolism andmechanisms for complex traits and diseases. We integrated lipidomics and genomics to unravel the genetic architecture ...

This year’s Meeting sponsored by AstraZeneca and GSK, will be held at the Centenary Institute on Thursday 17 and Friday 18 November.

About the talk: In this presentation, Connie will go through some of our recent published and unpublished work on the effect of stroke on the lung neutrophil function and gut barrier integrity. Connie and her team believe revealing the underlying mechanisms behind stroke-induced impairment of these vulnerable mucosal sites will lead to the discovery of ...

Ever wondered what it’s like to be a scientist?

Centenary’s Inclusion Gender Equity Program (IGEP) brings an entertaining and exciting half-day event

To honour Professor Mathew Vadas AO and his sixteen years as Executive Director of the Centenary Institute we will host a Symposium of Medical Research Excellence.

The Centenary Institute will host an Exhibition at Parliament House Sydney showcasing images taken by our scientists as part of their research endeavours that have both scientific significance and are visual masterpieces!  The Scientific Image Prize is an annual internal competition designed to recognise the incredible research of Centenary’s scientists, as well as their artistic ...

The 17th Annual NAMe meeting is a two day event designed to highlight emerging research in asthma and airways and to engage with new like-minded collaborators.

The 18th Annual NAMe meeting is a two day event designed to highlight emerging research in COPD, Asthma, Fibrosis, Microbiome and Bioinformatics as well as an opportunity to engage with new like-minded collaborators. Connect, Engage, Learn This year’s Meeting, sponsored by AstraZeneca, GSK and Cheisi, will be held at the Centenary Institute on Thursday 10 ...

Some of our leading cancer researchers, Professor Phil Hansbro, ProfessorÊPeter Hersey, Dr Mainthan Palendira and DrÊJessamy Tiffen have presented their project updates and recent findings to consumers and supporters at our recent consumer engagement session.

The official launch of the National Drug Discovery Centre (NDDC) has seen Centenary Institute researcher, Associate Professor Anthony Don, announced as one of the first recipients of Australian Government funding that will give him heavily subsidised access to the new CentreÕs advanced drug screening facilities. The opportunity will fast-track Associate Professor DonÕs research into treating type 2 diabetes.

The Centenary InstituteÕs Dr Stefan Oehlers (Immune-vascular Interactions Laboratory within the Tuberculosis Research Program), Dr Jessamy Tiffen (Melanoma Oncology and Immunology Program) and Dr Hui Emma Zhang (Liver Enzymes in Metabolism and Inflammation Program) have all been named on the EducatorÕs list of Higher Education Rising Stars for 2020.

Medical researchers at the Centenary Institute have focused their efforts to understand how the coronavirus is causing COVID-19 and are launching projects that will investigate a range of potential treatment strategies.

A group of leading Australian researchers have uncovered a unique blood-based biomarker signature in individuals infected by tuberculosis (TB).

Centenary Institute researchers have examined the critical role of human enzymes and the coronavirus in a newly published scientific review article that explores potential strategies for COVID-19 disease treatment and management.

Centenary Institute Deputy Director and Director of the Centenary UTS Centre for Inflammation, Professor Phil Hansbro has been elected as a Fellow of the European Respiratory Society (ERS).

Researchers from the Centenary Institute have discovered a potential new therapy for cerebral cavernous malformations (CCMs), a devastating disease that often affects young people and can result in stroke and seizures.

Understanding the long-term health impacts of bushfire smoke will be the focus of a new study being undertaken at the Centenary Institute and the University of Technology Sydney (UTS).

Australian researchers, including from the Centenary Institute have been awarded funding for a major project that aims to eliminate both active and latent tuberculosis (TB) found on Kiribati, an island nation in the central Pacific Ocean. The project will also support multidrug-resistant TB control education and management through the Pacific region.

Sydney researchers are taking an innovative approach to designing potential COVID-19 vaccines Ð using a tuberculosis vaccine to deliver components of the SARS-CoV-2 virus. Early results from pre-clinical testing in mice are promising.

Professor Phil Hansbro, Deputy Director at the Centenary Institute and Director of the Centenary UTS Centre for Inflammation has been interviewed by Prime7 News on his new study that will be focused on exploring the health impacts of peopleÕs exposure to bushfire smoke.

A collaborative project between the University of Sydney and the Centenary Institute to find a COVID-19 vaccine has been featured on 10 News.

The Centenary InstituteÕs Executive Director, Professor Mathew Vadas, together with other leading Australian researchers, have featured in a recent ABC News article, explaining that COVID-19 appears to be far more than just a respiratory disease.

Centenary Institute researcher Dr Claudio Counoupas has featured as a case study in a 2020 AAMRI (Association of Australian Medical Research Institutes) Budget Submission to Federal Government.

Centenary Institute researchers have outlined the crucial importance of diverse animal, cell and tissue model usage in the development of effective COVID-19 treatments and medications.

An international study led by the University of Glasgow, including collaborators from the Centenary Institute, has identified a new class of drugs that could pave the way to a new treatment for asthma and chronic obstructive pulmonary disease (COPD).

The first case of COVID-19 reinfection has been documented by scientists from Hong Kong who report that a 33 year old man has been infected by two different strains of the virus. The second infection occurred more than four months after recovery from the first episode of the disease.

The findings of an international study led by the Centenary Institute suggests that the possibility of high-risk drinkers developing alcohol-induced cirrhosis is in part related to genetic factors.

Research led by the Centenary Institute has shown that a healthy weight and coffee consumption may help lower the risk of high-risk drinkers developing alcohol-induced cirrhosis (scarring of the liver), which causes approximately 300,000 deaths globally each year.

Research led by the Centenary Institute has discovered that the lack of an enzyme in the liver called sphingosine kinase 2 (SphK2) results in pronounced insulin resistance and glucose intolerance, both symptoms of early stage type 2 diabetes.

Research from the Centenary Institute has found that the human enzyme dipeptidyl peptidase (DPP4) does not bind to the spike protein of the SARS-CoV-2 virus and so cannot enable COVID-19 infection in our bodies.

CentenaryÕs Summer Research Scholarship program for 2020/21 is now open and accepting applications!

Professor Phil Hansbro, Director of the Centenary UTS Centre for Inflammation has featured on the current affairs program 60 Minutes, explaining his critical research on bushfire smoke, its impact on the health of Australians and how his work could potentially lead to new prevention and treatment strategies.

Researchers at the Centenary Institute have found that sensitivity of the immune system to ÔgoodÕ gut bacteria is present in zebrafish, proving that the ability of an animal to benefit from good gut bugs is evolutionarily conserved whether you walk or swim.

Research led by the Centenary Institute, the University of Technology Sydney and the University of Queensland has shown for the first time a link between chronic obstructive pulmonary disease (COPD), an often fatal lung condition, and the gut microbiome.

The first study of human gene associations with severe COVID-19 has just been accepted for publication in the highly prestigious journal ÔNatureÕ.

World-leading research into sudden cardiac death (SCD) in young people and multiple sclerosis has been boosted with two Centenary Institute researchers successfully securing prestigious Ideas Grants in the latest round of National Health and Medical Research Council (NHMRC) funding.

Scientists in Australia have developed a method for the rapid synthesis of safe vaccines, an approach that can be used to test vaccine strategies against novel pandemic pathogens such as SARS-CoV-2, the virus that causes COVID-19.Ê

A team of Australian researchers, including from the Centenary Institute, has shown in a new study that older people and men tend to have higher levels of the enzyme ACE2 on the cells of their lower lungs - and that this may be the reason for their increased risk from COVID-19.

Associate Professor Anthony Don, Head of the Lipid Metabolism and Neurochemistry Laboratory at the Centenary Institute has received a funding grant of $115,000 from MS Research Australia to help investigate and develop drugs that can better treat multiple sclerosis (MS).

The Centenary InstituteÕs Summer Research Scholarship Program for undergraduate students has drawn to a close with 14 Êstudents undertaking a series of Ôrapid-fireÕ style presentations to staff, explaining their completed research projects and talking about their work-related experiences at Centenary over the summer months.

Dr Keshav Raj Paudel, an early career researcher at the Centenary UTS Centre for Inflammation has been awarded the prestigious ÔThoracic Society of Australia and New Zealand (TSANZ) Maurice Blackburn Grant-In-Aid for Occupational Lung DiseaseÕ for 2021.

A collaborative project involving the University of Sydney, the Centenary Institute, the University of Technology Sydney and the Kirby Institute at UNSW Sydney, has received funding from the Medical Research Future Fund (MRFF) to continue work on the development of a unique, single-shot vaccine against COVID-19 variants of concern.

The Centenary Institute has hosted the TB-CRE 2021 Symposium, which has showcased the latest tuberculosis research from international members and collaborators, and provided a platform for TB discussion and planning.

Research shows that inhibiting necroptosis, a form of cell death, could be a novel therapeutic approach for treating chronic obstructive pulmonary disease (COPD), an inflammatory lung condition, also known as emphysema, that makes it difficult to breathe.

Early career researchers from three of SydneyÕs leading medical research institutes, the Centenary Institute, the Heart Research Institute and the Woolcock Institute have come together to deliver the ÔECR Think Tank ProgramÕ for 2021.

The Centenary Institute has held its inaugural ‘Inflammation Symposium’ on 13 and 14 July, highlighting the latest in medical research across the field of inflammation and disease.

The Centenary Institute is pleased to note its involvement in, and support of, the newly announced NSW RNA Production and Research Network involving the stateÕs leading universities and other prominent health and medical research organisations.

Dr Matt Johansen from the Centenary UTS Centre for Inflammation has been interviewed by Carl Smith, journalist from the ABC Science Show.

Researchers from the Centenary UTS Centre for Inflammation and collaborators have been awarded a seed grant of $20,000 to advance a new treatment strategy for chronic obstructive pulmonary disease (COPD) patients suffering from influenza.

Dr Matt Johansen from the Centenary UTS Centre for Inflammation is the successful recipient of the Kenyon Foundation Inflammation Award for 2021.

Australian researchers have been awarded a $5 million National Health and Medical Research Council (NHMRC) Synergy Grant for a project that will advance knowledge of the gut, microbiomes, metabolites and diet, and their role in both causing and potentially treating inflammatory respiratory diseases, particularly chronic obstructive pulmonary disease (COPD).

An international research group led by the Centenary Institute has developed a world first genetic risk score (GRS) test able to identify patients at high-risk of developing alcohol-related cirrhosis.

Centenary Institute researchers have secured more than $2m in collective funding from the Federal Government in the latest round of National Health and Medical Research Council (NHMRC) Ideas Grants.

New research by the Centenary Institute suggests that commonly prescribed anticoagulants – medicines, such as aspirin, that help prevent blood clots – may make urinary tract infections (UTIs) more severe.

Australians will be better protected against the health impacts of climate change, thanks to the Healthy Environments And Lives (HEAL) national research network, just announced by the Australian Government.

Research led by the Centenary Institute and University of Technology Sydney has identified a small RNA molecule called microRNA-21 as a therapeutic target and its inhibition as a potential treatment for chronic obstructive pulmonary disease (COPD).

Centenary Institute researchers have uncovered new insight into Mycobacterium abscessus, a highly drug-resistant bacteria that can cause serious infection and lung damage in vulnerable people. The bacteria is considered an emerging health threat with infection numbers on the rise globally.

Professor Phil Hansbro, Director of the Centenary UTS Centre for Inflammation has featured in a Good Weekend article discussing the role of inflammation in health. Inflammation is increasingly being found to play crucial roles in the development of many major diseases, including Alzheimer’s, heart disease, cancer, respiratory diseases, diabetes, tuberculosis and COVID-19. “There’s been a ...

The Centre of Research Excellence in Tuberculosis Control (TB-CRE) has held a seminar at the Centenary Institute in support of World TB Day, 24 March 2022. TB, primarily affecting the lungs, is one of the world’s deadliest infectious killers. Every day, over 4,100 people die from TB world-wide and nearly 30,000 people fall ill with ...

Dr Annalicia Vaughan from the Centenary UTS Centre for Inflammation is the successful recipient of the Kenyon Foundation Inflammation Award for 2022.

Centenary Institute research has revealed new insight into tackling mycobacterial infections which are responsible for chronic diseases that include tuberculosis (TB), leprosy and serious skin ulcerations.

Researchers from the Centenary Institute and the University of Technology Sydney have published the first study showing why people with chronic obstructive pulmonary disease (COPD) are at higher risk of developing severe COVID-19.

Dr Elinor Hortle, medical researcher at the Centenary Institute has been interviewed on Sydney radio 2GB’s Healthy Living program, discussing her latest findings on tackling mycobacterial infections. Responsible for diseases that include tuberculosis (TB), leprosy and serious skin ulcerations, mycobacterial infections cause significant harm and mortality to human health. Approximately 1.5 million people die each ...

Hi, I’m A/Prof Devanshi Seth and I head Centenary’s Alcoholic Liver Disease Laboratory. 

Hi, I’m Mark and I’m Head of the Liver Enzymes in Metabolism and Inflammation Program at Centenary.

Hi, I’m Dr Hui Emma Zhang and I research liver cancer at Centenary.

Hi, I’m Patrick and I Head the Liver Immunology Program at Centenary.

Hi, I’m Dr Claudio Counoupas and I research tuberculosis at Centenary.

Hi, I’m Elinor and I’m post-doctorate researcher at Centenary.

Hi, I'm Nick and I'm the Chief Operating Officer at Centenary.

Hi, I'm Katrina and I'm in charge of Translation and Commercialisation at Centenary.

Hi, I’m Kristina and my job is to ensure that our high-tech state-of-the-art microscopes at Centenary are operating well and that all staff, including students, know how to use them correctly for their research.

A medical researcher at the Centenary UTS Centre for Inflammation, Dr Annalicia Vaughan specialises in the gut-lung axis and its role in lung and respiratory diseases.

Dr Joyce Chiu from the ACRF Centenary Cancer Research Centre has won an Oral Communication Award for her talk given at the 15th World Congress on Inflammation, held in Rome, June 2022.

Researchers at the Centenary Institute and the University of Technology Sydney have identified a new drug target for the treatment and prevention of chronic obstructive pulmonary disease (COPD), an inflammatory lung disease that causes airway blockage and that makes it difficult to breathe.

A group of Australian researchers, including Professor Phil Hansbro, Director of the Centenary UTS Centre for Inflammation, have won a Fukuchi (Respirology) Award for ‘outstanding original research paper’ published in the journal Respirology.

The Centenary Institute has engaged with kids and the wider community as the Research Partner of Sydney Science Trail held at the Botanic Gardens and Australian Museum in celebration of National Science Week.

Researchers, including from the Centenary Institute, have reported that ultra-low levels of the dipeptidyl peptidase 9 (DPP9) enzyme could be contributing to immune disorders in children.

The Centenary Institute’s Professor Phil Hansbro, Director of the Centenary UTS Centre for Inflammation has been appointed as an editorial board member of the highly respected and high impact American Journal of Respiratory and Critical Care Medicine (also known as the ‘Blue Journal’).

Centenary Institute PhD student, Mark Man Gia Ly has been awarded the Royal Prince Alfred Hospital Medical Officers Association President Prize for Laboratory Research.

The Centenary Institute has given members of the public, school students and stakeholders the opportunity to find out what it’s like to be a scientist – and to better understand what it takes to be at the cutting-edge of medical discovery – with its unique ‘speed dating’ event, held as part of the Spark Festival.

Centenary Institute and University of Sydney PhD student, Lina Daniel, is lead author on a newly published paper that has found that Mycobacterium tuberculosis remodels the architecture of the lymph nodes – limiting the immune system’s ability to overcome tuberculosis (TB) infection.

Clinical Professor Devanshi Seth, Head of the Centenary Institute’s Alcoholic Liver Disease Laboratory is co-author on a newly published study that has identified factors affecting mortality in people drinking extreme amounts of alcohol.

Researchers from the Centenary Institute and the University of Sydney have developed a new nasal vaccination strategy that induces potent lung immunity and protection against the SARS-CoV-2 coronavirus.

The Centenary UTS Centre for Inflammation has hosted the 16th Annual NSW Asthma Meeting (NAMe) held at the Centenary Institute, 17-18 November 2022.

Macrophages are specialised cells from our immune system.

Research led by the Centenary Institute and the University of Sydney – focused on the development of a new nasal COVID-19 vaccine – has received close to $1m in grant funding from the NSW COVID-19 Vaccine Acceleration Research Grants Program.

Research led by the Centenary Institute, the University of Technology Sydney and Ghent University Hospital, Belgium has identified a new therapeutic approach for chronic obstructive pulmonary disease (COPD) – the targeting and inhibition of a protein called RIPK1.